Could Aging Human Skin Use a Connective Tissue Growth Factor Boost to Increase Collagen Content?

被引：31
|
作者：
Oliver, Noelynn [1 ]
Sternlicht, Mark [1 ]
Gerritsen, Karin [2 ]
Goldschmeding, Roel [1 ,2 ]
机构：
[1] FibroGen Inc, Therapeut Res, San Francisco, CA 94080 USA
[2] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2010年 / 130卷 / 02期
关键词：
FACTOR CTGF; EXPRESSION; CYR61; PROGRESSION; ACTIVATION;
D O I：
10.1038/jid.2009.331
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The roles of connective tissue growth factor ( CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
引用
收藏
页码：338 / 341
页数：5
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