Could Aging Human Skin Use a Connective Tissue Growth Factor Boost to Increase Collagen Content?

被引：31
|
作者：
Oliver, Noelynn [1 ]
Sternlicht, Mark [1 ]
Gerritsen, Karin [2 ]
Goldschmeding, Roel [1 ,2 ]
机构：
[1] FibroGen Inc, Therapeut Res, San Francisco, CA 94080 USA
[2] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2010年 / 130卷 / 02期
关键词：
FACTOR CTGF; EXPRESSION; CYR61; PROGRESSION; ACTIVATION;
D O I：
10.1038/jid.2009.331
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The roles of connective tissue growth factor ( CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
引用
收藏
页码：338 / 341
页数：5
相关论文
共 50 条
  • [1] Connective tissue growth factor:: A key regulator of collagen production is reduced in aged human skin in vivo
    Fisher, G
    Quan, T
    Kang, S
    Voorhees, J
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (03) : A16 - A16
  • [2] AGING OF HUMAN CONNECTIVE-TISSUE - INCREASE IN THE CONTENT OF A CROSSLINKING AMINO-ACID, HISTIDINOALANINE
    FUJIMOTO, D
    BIOCHEMISTRY INTERNATIONAL, 1982, 5 (06): : 743 - 746
  • [3] Elevated expression of connective tissue growth factor, osteopontin and increased collagen content in human ascending thoracic aortic aneurysms
    Meng, Y. H.
    Tian, C.
    Liu, L.
    Wang, L.
    Chang, Q.
    VASCULAR, 2014, 22 (01) : 20 - 27
  • [4] AIRWAY CONNECTIVE TISSUE GROWTH FACTOR AND FIBRILLAR COLLAGEN IN COPD
    Tjin, G.
    Noble, P.
    James, A.
    Mcparland, B.
    Jones, R.
    Kable, E.
    Burgess, J.
    RESPIROLOGY, 2014, 19 : 60 - 60
  • [5] Effects of connective tissue growth factor and collagen type Ⅰ scleroderma
    Xiaoning Yan
    The Journal of Biomedical Research, 2007, (03) : 175 - 179
  • [6] Reduction of transforming growth factor-β/Smad/connective tissue growth factor axis contributes to loss of type I collagen in aged human skin in vivo
    Fisher, G. J.
    Quan, T. H.
    He, T. Y.
    Shao, Y.
    Kang, S.
    Voorhees, J. J.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 : S34 - S34
  • [7] Retinoid induction of transforming growth factor-β1 and connective tissue growth factor:: Major regulators of collagen synthesis, in aged and photoaged human skin in vivo
    He, T
    Quan, TH
    Fisher, GJ
    Voorhees, JJ
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (01) : 229 - 229
  • [8] Connective tissue growth factor mediates transforming growth factor β-induced collagen expression in human endometrial stromal cells
    Cheong, Mei-Leng
    Lai, Tsung-Hsuan
    Wu, Wen-Bin
    PLOS ONE, 2019, 14 (01):
  • [9] Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts
    Zhu, MJ
    Kim, CD
    Kwon, YB
    Kye, KC
    Chen, YY
    Lee, WH
    Lee, S
    Lim, JS
    Seo, YJ
    Suhr, KB
    Park, JK
    Lee, JH
    EXPERIMENTAL DERMATOLOGY, 2005, 14 (07) : 509 - 514
  • [10] Connective tissue growth factor:: Expression in human skin in vivo and inhibition by ultraviolet irradiation
    Quan, TH
    He, TY
    Kang, SW
    Voorhees, JJ
    Fisher, GJ
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 118 (03) : 402 - 408
12345