SYNTHESIS OF 6,7,8,9-TETRAHYDRO-5H-1-THIA-5,10-DIAZA-CYCLOHEPTA[f]INDEN-4-YLAMINE DERIVATIVES

被引：8
|
作者：
Song, Yang-Heon [1 ]
Joe, Byeoung Sun [1 ]
Lee, Han Mi [1 ]
机构：
[1] Mokwon Univ, Dept Chem, Taejon 302729, South Korea
来源：
HETEROCYCLIC COMMUNICATIONS | 2009年 / 15卷 / 03期
关键词：
ACETYLCHOLINESTERASE INHIBITORS; ALZHEIMERS-DISEASE;
D O I：
10.1515/HC.2009.15.3.203
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper describes the synthesis of 6,7,8,9-tetrahydro-5H-1-thia-5,10-diazacyclohepta[f]inden-4-ylamine derivatives in good yield by four-step procedures starting from 2-aminothiophene-3-carbonitrile and 5-substituted cyclohexane- 1,3-dione.
引用
收藏
页码：203 / 207
页数：5
相关论文
共 50 条
  • [21] Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT2C agonists for the treatment of metabolic disorders
    Tye, Heather
    Mueller, Stephan G.
    Prestle, Juergen
    Scheuerer, Stefan
    Schindler, Marcus
    Nosse, Bernd
    Prevost, Natacha
    Brown, Christopher J.
    Heifetz, Alexander
    Moeller, Clemens
    Pedret-Dunn, Anna
    Whittaker, Mark
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (01) : 34 - 37
  • [22] STEREOCHEMISTRY OF EPHEDRINE-LIKE COMPOUNDS - ABSOLUTE CONFIGURATION OF 4 ISOMERIC CIS-6-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTENOLS-(5) AND TRANS-6-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTENOLS-(5)
    MOHR, G
    ZYMALKOW.F
    FRAHM, AW
    ANNALEN DER CHEMIE-JUSTUS LIEBIG, 1972, 756 (NFEB): : 103 - &
  • [23] REACTIONS OF SOME DERIVATIVES OF DIHYDRO AND TETRAHYDROBENZOCYCLOHEPTENONES .2. SYNTHESIS OF BENZAMIDO DERIVATIVES OF 6,7,8,9-TETRAHYDRO-(5H)-BENZOCYCLOHEPTENE-5-ONE
    KOTKOWSKAMACHNIK, Z
    ZAKRZEWSKI, J
    POLISH JOURNAL OF CHEMISTRY, 1979, 53 (11) : 2363 - 2366
  • [24] SYNTHESIS OF CIS- AND TRANS-6-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5-OLS
    KHANNA, JM
    BOLGER, J
    ANAND, N
    INDIAN JOURNAL OF CHEMISTRY, 1969, 7 (06): : 550 - &
  • [25] SYNTHESIS OF 6,7,8,9-TETRAHYDRO-5H-PYRIMIDO-[4,5-B][1,4]DIAZEPINE-6,8-DIONES
    PHILLIPS, OA
    KNAUS, EE
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (01) : 283 - 285
  • [26] Synthesis of 6-oxo-6,7,8,9-tetrahydro-10H-pyrimido-[5,4-b][1,4]benzoxazines and 6-oxo-6,7,8,9-tetrahydropyrimido[4,5-b][1,4]benzodioxanes
    Sazonov N.V.
    Mamaeva I.E.
    Safonova T.S.
    Chemistry of Heterocyclic Compounds, 1998, 34 (10) : 1201 - 1206
  • [27] Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
    Hawryluk, Natalie A.
    Merit, Jeffrey E.
    Lebsack, Alec D.
    Branstetter, Bryan J.
    Hack, Michael D.
    Swanson, Nadia
    Ao, Hong
    Maher, Michael P.
    Bhattacharya, Anindya
    Wang, Qi
    Freedman, Jamie M.
    Scott, Brian P.
    Wickenden, Alan D.
    Chaplan, Sandra R.
    Breitenbucher, J. Guy
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 7137 - 7141
  • [28] SHORT, EFFICIENT, SYNTHETIC PATHWAY TO THE 6,7,8,9-TETRAHYDRO-5H-DIBENZ[D,F]AZONINE SYSTEM
    BRANDT, S
    MARFAT, A
    HELQUIST, P
    TETRAHEDRON LETTERS, 1979, (24) : 2193 - 2194
  • [29] 1-2 AND 1-4 CYCLOADDITIONS OF DICHLOROKETENE TO 6-DIETHYLAMINOETHYLENE-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5-ONE
    MOSTI, L
    BIGNARDI, G
    SCHENONE, P
    MENOZZI, G
    CHIMICA & L INDUSTRIA, 1977, 59 (04): : 302 - 302
  • [30] SYNTHESES OF 6-AMINO-1,2-DIHYDROXY-6,7,8,9-TETRAHYDRO-5H-BENZO-CYCLOHEPTEN-5-OL DERIVATIVES
    ITOH, K
    SUGIHARA, H
    MIYAKE, A
    TADA, N
    OKA, Y
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1978, 26 (02) : 504 - 513
12345