Development and Preclinical Characterization of an Fc-Optimized CD133 Antibody for Induction of NK Cell Reactivity Against Myeloid Leukemia

被引：2
|
作者：
Koerner, Samuel [1 ]
Leibold, Julia [1 ]
Grosse-Hovest, Ludger [2 ]
Buehring, Hans-Joerg [1 ]
Jung, Gundram [1 ]
Kanz, Lothar [3 ]
Salih, Helmut R. [1 ,4 ,5 ]
机构：
[1] Univ Tubingen, Tubingen, Germany
[2] SYNIMMUNE GmbH, Tubingen, Germany
[3] Univ Hosp Tuebingen, Tubingen, Germany
[4] German Canc Consortium DKTK, Heidelberg, Germany
[5] German Canc Res Ctr, Heidelberg, Germany
来源：
BLOOD | 2014年 / 124卷 / 21期
关键词：
D O I：
10.1182/blood.V124.21.2309.2309
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Reduction of Minimal Residual Disease in Pediatric B-lineage Acute Lymphoblastic Leukemia by an Fc-optimized CD19 Antibody
    Seidel, Ursula Joerdis Eva
    Schlegel, Patrick
    Grosse-Hovest, Ludger
    Hofmann, Martin
    Aulwurm, Steffen
    Pyz, Elwira
    Schuster, Friedhelm R.
    Meisel, Roland
    Ebinger, Martin
    Feuchtinger, Tobias
    Teltschik, Heiko-Manuel
    Witte, Kai-Erik
    Schwarze, Carl-Philipp
    Rammensee, Hans-Georg
    Handgretinger, Rupert
    Jung, Gundram
    Lang, Peter
    MOLECULAR THERAPY, 2016, 24 (09) : 1634 - 1643
  • [32] Phase I trial of the Fc-optimized FLT3 antibody FLYSYN in acute myeloid leukemia (AML) patients with measurable residual disease
    Heitmann, J. S.
    Doerfel, D.
    Kayser, S.
    Doehner, K.
    Heuser, M.
    Thol, F.
    Kapp-Schwoerer, S.
    Bethge, W.
    Grosse-Hovest, L.
    Steiner, M.
    Maerklin, M.
    Walz, J.
    Schlenk, R.
    Jung, G.
    Salih, H.
    ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (SUPPL 4) : 31 - 31
  • [33] CD133/FLT3 immunocytokines with target cell-restricted IL-15 activity for induction of NK cell immunity against AML
    Schmied, B. J.
    Maerklin, M.
    Zekri-Metref, L.
    Pflugler, M.
    Kanz, L.
    Jung, G.
    Salih, H. R.
    ONCOLOGY RESEARCH AND TREATMENT, 2017, 40 : 9 - 9
  • [34] Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia
    Han, Yoon-Chi
    Kahler, Jennifer
    Piche-Nicholas, Nicole
    Hu, Wenyue
    Thibault, Stephane
    Jiang, Fan
    Leal, Mauricio
    Katragadda, Madan
    Maderna, Andreas
    Dushin, Russell
    Prashad, Nadira
    Charati, Manoj B.
    Clark, Tracey
    Tumey, L. Nathan
    Tan, Xingzhi
    Giannakou, Andreas
    Rosfjord, Edward
    Gerber, Hans-Peter
    Tchistiakova, Lioudmila
    Loganzo, Frank
    O'Donnell, Christopher J.
    Sapra, Puja
    CLINICAL CANCER RESEARCH, 2021, 27 (02) : 622 - 631
  • [35] Immunocytokines with Target Cell-Restricted IL-15 Activity for Induction of NK Cell Reactivity Against Acute Myeloid Leukemia (AML)
    Schmied, Bastian J.
    Zekri, Latifa
    Pfluegler, Martin
    Maerklin, Melanie
    Kanz, Lothar
    Jung, Gundram
    Salih, Helmut R.
    BLOOD, 2018, 132
  • [36] Interim Results of a First in Man Study with the Fc-Optimized FLT3 Antibody Flysyn for Treatment of Acute Myeloid Leukemia with Minimal Residual Disease
    Kayser, Sabine
    Heitmann, Jonas S.
    Doerfel, Daniela
    Thol, Felicitas
    Heuser, Michael
    Maerklin, Melanie
    Mueller-Tidow, Carsten
    Steiner, Martin
    Grosse-Hovest, Ludger
    Jung, Gundram
    Schlenk, Richard F.
    Salih, Helmut R.
    BLOOD, 2019, 134
  • [37] Induction of NK cell reactivity against AML and CLL cells by Fc-engineered GITR-Fc fusion proteins
    Hilpert, J.
    Schmiedel, B. J.
    Werner, A.
    Nuebling, T.
    Buechele, C.
    Grosse-Hovest, L.
    Kanz, L.
    Salih, H. R.
    ONKOLOGIE, 2012, 35 : 57 - 58
  • [38] Fc-Optimized NKG2D-Fc Constructs Induce NK Cell Antibody-Dependent Cellular Cytotoxicity against Breast Cancer Cells Independently of HER2/neu Expression Status
    Raab, Stefanie
    Steinbacher, Julia
    Schmiedel, Benjamin J.
    Kousis, Philaretos C.
    Steinle, Alexander
    Jung, Gundram
    Grosse-Hovest, Ludger
    Salih, Helmut R.
    JOURNAL OF IMMUNOLOGY, 2014, 193 (08): : 4261 - 4272
  • [39] Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia
    Maerklin, Melanie
    Hagelstein, Ilona
    Koerner, Samuel P.
    Rothfelder, Kathrin
    Pfluegler, Martin S.
    Schumacher, Andreas
    Grosse-Hovest, Ludger
    Jung, Gundram
    Salih, Helmut R.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [40] INDUCTION OF FC-EPSILON-RII/CD23 ON HUMAN MYELOID AND NK CELL-LINES
    YODOI, J
    UEDA, Y
    MAEKAWA, N
    SUGIE, K
    KAWABE, T
    KITAOKA, Y
    UCHIDA, A
    FASEB JOURNAL, 1992, 6 (04): : A1401 - A1401
12345