Getting the Skinny on CD4+ T Cell Survival in Fatty Livers

被引：2

作者：

Walker, Christopher M. ^{[1
,2
]}

Lemon, Stanley M. ^{[3
,4
]}

机构：

[1] Ohio State Univ, Nationwide Childrens Hosp, Ctr Vaccines & Immun, Columbus, OH 43205 USA

[2] Ohio State Univ, Dept Pediat, Coll Med, Columbus, OH 43205 USA

[3] Univ N Carolina, Dept Med, Div Infect Dis, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27517 USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27517 USA

来源：

IMMUNITY | 2016年 / 44卷 / 04期

关键词：

HEPATOCELLULAR-CARCINOMA; IMMUNOTHERAPY;

D O I：

10.1016/j.immuni.2016.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Non-alcoholic fatty liver disease is associated with hepatocellular carcinoma. In the March 10 issue of Nature, Greten and colleagues report that this metabolic disruption affects tumor surveillance by depleting CD4+ T helper cells through lipotoxic mechanisms associated with NAFLD.

引用

页码：725 / 727

页数：3

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