Getting the Skinny on CD4+ T Cell Survival in Fatty Livers

被引：2
|
作者：
Walker, Christopher M. [1 ,2 ]
Lemon, Stanley M. [3 ,4 ]
机构：
[1] Ohio State Univ, Nationwide Childrens Hosp, Ctr Vaccines & Immun, Columbus, OH 43205 USA
[2] Ohio State Univ, Dept Pediat, Coll Med, Columbus, OH 43205 USA
[3] Univ N Carolina, Dept Med, Div Infect Dis, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27517 USA
[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27517 USA
来源：
IMMUNITY | 2016年 / 44卷 / 04期
关键词：
HEPATOCELLULAR-CARCINOMA; IMMUNOTHERAPY;
D O I：
10.1016/j.immuni.2016.04.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Non-alcoholic fatty liver disease is associated with hepatocellular carcinoma. In the March 10 issue of Nature, Greten and colleagues report that this metabolic disruption affects tumor surveillance by depleting CD4+ T helper cells through lipotoxic mechanisms associated with NAFLD.
引用
收藏
页码：725 / 727
页数：3
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