Effect of dietary carboxymethyl chitosans on the levels of iron, zinc and copper in mice

被引：4

作者：

Wang, Wei ^{[1
]}

Qin, Caiqin ^{[1
]}

Ding, Yu ^{[1
]}

Peng, Huie ^{[1
]}

Wang, Liansheng ^{[1
]}

机构：

[1] Xiaogan Univ, Lab Nat Polysaccharides, Xiaogan 432000, Hubei, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2010年 / 81卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Carboxymethyl chitosan; Trace element; Mouse; Oral administration; STABLE-ISOTOPE; ABSORPTION; BIOAVAILABILITY; DERIVATIVES; RETENTION; ELEMENTS; PHYTATE; CHITIN; IONS;

D O I：

10.1016/j.carbpol.2010.02.035

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three carboxymethyl chitosan samples were prepared by the carboxymethylation of chitosans with different molecular weights (Mw). These samples (0.75%, w/w) in diet were fed mice for 30 days. Afterwards no pathological symptoms, clinical signs or deaths were observed. The body weights of mice in carboxymethyl chitosan groups and control group showed no significant difference. These carboxymethyl chitosan samples did not decrease the level of copper in the tested mice's organs. However, the level of iron in the tested mice's livers and lungs, and the level of zinc in the tested mice's livers, lungs, hearts, spleens, thymuses and kidneys were significantly decreased by oral administration of these samples. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：203 / 206

页数：4

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