Multicentric Castleman's disease presenting with mediastinal disease in a HIV infected patient.

Castleman's disease is most often seen by a thoracic physician as a mediastinal tumour which is discovered fortuitously and,whose surgical excision leads to a cure. We report a case of a patient of 30 who was seropositive for HN and was suffering from Castleman's disease initially localisased to the mediastinum The disease was associated with a cutaneous and bronchial Kaposi sarcoma. The mediastinal disease, associated with cutaneous and bronchial Kaposi sarcoma, was marked by evolving in a multicentric manner. We review the histological definition and recent data concerning the pathophysiology and the diagnostic and therapeutic management of this disorder and the very varied clinical expression.