Programmed cell death regulation: basic mechanisms and therapeutic opportunities

被引：30
|
作者：
Johnson, DE
机构：
[1] Univ Pittsburgh, Dept Med, Div Hematol Oncol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Ctr Canc, Pittsburgh, PA USA
来源：
LEUKEMIA | 2000年 / 14卷 / 08期
关键词：
apoptosis; mitochondria; Bcl-2; caspase; IAP; TRAIL;
D O I：
10.1038/sj.leu.2401849
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The molecular mechanisms responsible for induction or inhibition of apoptosis signal transduction have been intensively investigated during the past few years. Information gained from mechanistic studies and from structural analysis of apoptosis regulatory proteins has provided considerable insight into the pathways that determine whether a cell will live or die. Many of these advances were recently presented at the American Association for Cancer Research Special Conference on 'Programmed Cell Death Regulation: Basic Mechanisms and Therapeutic Opportunities'. This mini-review will discuss the current state of knowledge regarding apoptosis signaling pathways and the function of apoptosis regulatory proteins.
引用
收藏
页码：1340 / 1344
页数：5
相关论文
共 50 条
  • [31] Redox regulation in plant programmed cell death
    De Pinto, M. C.
    Locato, V.
    De Gara, L.
    PLANT CELL AND ENVIRONMENT, 2012, 35 (02): : 234 - 244
  • [32] Life, death and kidneys: regulation of renal programmed cell death
    Sorenson, CM
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 1998, 7 (01): : 5 - 12
  • [33] mTOR in programmed cell death and its therapeutic implications
    Xie, Yawen
    Lei, Xianli
    Zhao, Guoyu
    Guo, Ran
    Cui, Na
    CYTOKINE & GROWTH FACTOR REVIEWS, 2023, 71-72 : 66 - 81
  • [34] Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets
    An, Yuepeng
    Zhao, Fu
    Jia, Hongling
    Meng, Siyu
    Zhang, Ziwei
    Li, Shuxiao
    Zhao, Jiusi
    DISCOVER ONCOLOGY, 2025, 16 (01)
  • [35] Resistance mechanisms to programmed cell death protein 1 and programmed death ligand 1 inhibitors
    Pezeshki, Parmida Sadat
    Mahdavi Sharif, Pouya
    Rezaei, Nima
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2021, 21 (12) : 1575 - 1590
  • [36] Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy
    Scimeca, Manuel
    Rovella, Valentina
    Palumbo, Valeria
    Scioli, Maria Paola
    Bonfiglio, Rita
    Melino, Gerry
    Piacentini, Mauro
    Frati, Luigi
    Agostini, Massimiliano
    Candi, Eleonora
    Mauriello, Alessandro
    CANCERS, 2023, 15 (14)
  • [37] Circular RNAs in programmed cell death: Regulation mechanisms and potential clinical applications in cancer: A review
    Gao, Yudi
    Lin, Hong
    Tang, Tiantian
    Wang, Yuanqiang
    Chen, Wanyi
    Li, Lixian
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 280
  • [38] CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
    Franklin, Robin J. M.
    Simons, Mikael
    NEURON, 2022, 110 (21) : 3549 - 3565
  • [39] Mechanisms of programmed cell death in Caenorhabditis elegans and vertebrates
    Miura, M
    Yuan, JY
    CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 32, 1996, 32 : 139 - 174
  • [40] MECHANISMS OF PROGRAMMED CELL-DEATH AND THEIR IMPLICATIONS FOR THE BRAIN
    ROSE, CD
    HENNEBERRY, RC
    NEURODEGENERATION, 1993, 2 (04): : 287 - 297
12345