Programmed cell death regulation: basic mechanisms and therapeutic opportunities

被引：30
|
作者：
Johnson, DE
机构：
[1] Univ Pittsburgh, Dept Med, Div Hematol Oncol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Ctr Canc, Pittsburgh, PA USA
来源：
LEUKEMIA | 2000年 / 14卷 / 08期
关键词：
apoptosis; mitochondria; Bcl-2; caspase; IAP; TRAIL;
D O I：
10.1038/sj.leu.2401849
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The molecular mechanisms responsible for induction or inhibition of apoptosis signal transduction have been intensively investigated during the past few years. Information gained from mechanistic studies and from structural analysis of apoptosis regulatory proteins has provided considerable insight into the pathways that determine whether a cell will live or die. Many of these advances were recently presented at the American Association for Cancer Research Special Conference on 'Programmed Cell Death Regulation: Basic Mechanisms and Therapeutic Opportunities'. This mini-review will discuss the current state of knowledge regarding apoptosis signaling pathways and the function of apoptosis regulatory proteins.
引用
收藏
页码：1340 / 1344
页数：5
相关论文
共 50 条
  • [1] Programmed cell death regulation: basic mechanisms and therapeutic opportunities
    DE Johnson
    Leukemia, 2000, 14 : 1340 - 1344
  • [2] Therapeutic regulation of programmed cell death
    Kliche, KO
    JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 1999, 8 (04): : 321 - 322
  • [3] Oxidative cell death in cancer: mechanisms and therapeutic opportunities
    An, Xiaoqin
    Yu, Wenfeng
    Liu, Jinbao
    Tang, Daolin
    Yang, Li
    Chen, Xin
    CELL DEATH & DISEASE, 2024, 15 (08):
  • [4] Programmed cell death in hepatocellular carcinoma: mechanisms and therapeutic prospects
    Wu, Xiang'an
    Cao, Jingying
    Wan, Xueshuai
    Du, Shunda
    CELL DEATH DISCOVERY, 2024, 10 (01)
  • [5] Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets
    Qian, Shen'er
    Tan, Guolin
    Lei, Guang
    Zhang, Xiaowei
    Xie, Zuozhong
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2025, 1880 (01):
  • [6] Stresses make microbe undergo programmed cell death: Mechanisms and opportunities
    Liu, Chunhui
    Mao, Xiangzhao
    Meng, Lingyun
    Li, Jiao
    FOOD RESEARCH INTERNATIONAL, 2022, 151
  • [7] Mechanisms of programmed cell death
    Li, Tian
    Kroemer, Guido
    IMMUNOLOGICAL REVIEWS, 2024, 321 (01) : 5 - 6
  • [8] Programmed cell death in the retina.: Molecular mechanisms and therapeutic strategies
    Kermer, R
    Bähr, M
    OPHTHALMOLOGE, 2005, 102 (07): : 674 - 678
  • [9] Death ligands and granulysin: mechanisms of tumor cell death induction and therapeutic opportunities
    Martinez-Lostao, Luis
    de Miguel, Diego
    Al-Wasaby, Sameer
    Gallego-Lleyda, Ana
    Anel, Alberto
    IMMUNOTHERAPY, 2015, 7 (08) : 883 - 898
  • [10] Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation
    Kagan, Valerian E.
    Tyurina, Yulia Y.
    Vlasova, Irina I.
    Kapralov, Alexander A.
    Amoscato, Andrew A.
    Anthonymuthu, Tamil S.
    Tyurin, Vladimir A.
    Shrivastava, Indira H.
    Cinemre, Fatma B.
    Lamade, Andrew
    Epperly, Michael W.
    Greenberger, Joel S.
    Beezhold, Donald H.
    Mallampalli, Rama K.
    Srivastava, Apurva K.
    Bayir, Hulya
    Shvedova, Anna A.
    FRONTIERS IN ENDOCRINOLOGY, 2021, 11
12345