Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the UK: an early data-driven analysis

被引：52

作者：

Zhao, Shi ^{[1
,2
]}

Lou, Jingzhi ^{[1
]}

Cao, Lirong ^{[1
]}

Zheng, Hong ^{[1
]}

Chong, Marc K. C. ^{[1
,2
]}

Chen, Zigui ^{[3
]}

Chan, Renee W. Y. ^{[4
]}

Zee, Benny C. Y. ^{[1
,2
]}

Chan, Paul K. S. ^{[3
]}

Wang, Maggie H. ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China

[2] CUHK Shenzhen Res Inst, Shenzhen, Peoples R China

[3] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Peoples R China

来源：

JOURNAL OF TRAVEL MEDICINE | 2021年 / 28卷 / 02期

基金：

中国国家自然科学基金;

关键词：

COVID-19; mutation; transmission advantage; reproduction number; statistical modelling; B.1.1.7; lineage;

D O I：

10.1093/jtm/taab011

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The emerging N501Y mutation in severe acute respiratory syndrome coronavirus 2, which becomes prevalent in the UK rapidly, is one of the major challenges of COVID-19 control. To explore the transmission advantage, we estimate that the N501Y substitution increases the infectivity by 52% (95% confidence interval: 46, 58) in terms of the reproduction number.

引用

页数：3

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