Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the UK: an early data-driven analysis

被引：52
|
作者：
Zhao, Shi [1 ,2 ]
Lou, Jingzhi [1 ]
Cao, Lirong [1 ]
Zheng, Hong [1 ]
Chong, Marc K. C. [1 ,2 ]
Chen, Zigui [3 ]
Chan, Renee W. Y. [4 ]
Zee, Benny C. Y. [1 ,2 ]
Chan, Paul K. S. [3 ]
Wang, Maggie H. [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
[2] CUHK Shenzhen Res Inst, Shenzhen, Peoples R China
[3] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Peoples R China
来源：
JOURNAL OF TRAVEL MEDICINE | 2021年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
COVID-19; mutation; transmission advantage; reproduction number; statistical modelling; B.1.1.7; lineage;
D O I：
10.1093/jtm/taab011
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The emerging N501Y mutation in severe acute respiratory syndrome coronavirus 2, which becomes prevalent in the UK rapidly, is one of the major challenges of COVID-19 control. To explore the transmission advantage, we estimate that the N501Y substitution increases the infectivity by 52% (95% confidence interval: 46, 58) in terms of the reproduction number.
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页数：3
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