GS-0976, a Liver-Targeted Acetyl-CoA Carboxylase (ACC) Inhibitor, Reduces Plasma Acylcarnitines in Patients with Nonalcoholic Steatohepatitis (NASH)

被引：0

作者：

Charlton, Michael R. ^{[1
]}

Lai, Michelle ^{[2
,3
]}

Noureddin, Mazen ^{[4
]}

Tarrant, Jacqueline M. ^{[5
]}

Wang, Lulu ^{[5
]}

Tuan Nguyen ^{[5
]}

McColgan, Bryan John ^{[5
]}

Chung, Chuhan ^{[5
]}

Patterson, Scott D. ^{[5
]}

Myers, Robert P. ^{[5
]}

Mantry, Parvez ^{[6
]}

Ruane, Peter J. ^{[7
]}

Loomba, Rohit ^{[8
]}

机构：

[1] Univ Chicago, Chicago, IL 60637 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[3] Harvard Med Sch, Boston, MA USA

[4] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[5] Gilead Sci Inc, Foster City, CA 94404 USA

[6] Methodist Dallas Med Ctr, Liver Inst & Intervent Radiol, Dallas, TX USA

[7] Ruane Clin Res, Los Angeles, CA USA

[8] Univ Calif San Diego, Div Gastroenterol, NAFLD Res Ctr, San Diego, CA 92103 USA

来源：

HEPATOLOGY | 2018年 / 68卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

1741

引用

页码：992A / 993A

页数：2

共 37 条

[31] COMBINATION OF AN ACETYL-CoA CARBOXYLASE (ACC) INHIBITOR AND FIBROBLAST GROWTH FACTOR 19 (FGF19) REDUCED TISSUE TRIGLYCERIDE CONTENT AND FIBROSIS IN A 3D HUMAN LIVER MICROTISSUE MODEL OF NONALCOHOLIC STEATOHEPATITIS (NASH)
Tsai, Wen-Wei
Bieri, Manuela
Grepper, Sue
Thoma, Eva
Trevaskis, James L.
HEPATOLOGY, 2021, 74 : 1133A - 1133A
[32] A combination of the ACC inhibitor GS-0976 and the nonsteroidal FXR agonist GS-9674 improves hepatic steatosis, biochemistry, and stiffness in patients with non-alcoholic steatohepatitis
Lawitz, Eric
Gane, Edward
Ruane, Peter
Herring, Jr. Robert
Younes, Ziad H.
Kwo, Paul
Zhang, Jie
Jia, Catherine
Chuang, Jay
Mccolgan, Bryan
Chung, Chuhan
Subramanian, Mani
Myers, Robert
Middleton, Michael
Li, Kelvin
Hellerstein, Marc
Noureddin, Mazen
Harrison, Stephen
Loomba, Rohit
JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E794 - E794
[33] A combination of the ACC inhibitor GS-0976 and the nonsteroidal FXR agonist GS-9674 improves hepatic steatosis, biochemistry, and stiffness in patients with non-alcoholic steatohepatitis
Lawitz, Eric
Gane, Edward
Ruane, Peter
Herring, Robert, Jr.
Younes, Ziad H.
Kwo, Paul
Zhang, Jie
Jia, Catherine
Chuang, Jay
McColgan, Bryan
Chung, Chuhan
Subramanian, Mani
Myers, Robert
Thali, Ramon
Middleton, Michael
Li, Kelvin
Hellerstein, Marc
Noureddin, Mazen
Harrison, Stephen
Loomba, Rohit
SWISS MEDICAL WEEKLY, 2019, : 25S - 25S
[34] Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Firsocostat, a Liver-Targeted Inhibitor of Acetyl-CoA Carboxylase
Weber, Elijah J.
Younis, Islam R.
Nelson, Cara
Qin, Ann R.
Watkins, Timothy R.
Othman, Ahmed A.
CLINICAL PHARMACOKINETICS, 2024, 63 (10) : 1423 - 1434
[35] PF-05221304 (PF'1304), A LIVER-TARGETED ACETYL-CoA CARBOXYLASE INHIBITOR (ACCI), IN ADULTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) DEMONSTRATES ROBUST REDUCTIONS IN LIVER FAT AND ALT - PHASE 2a, DOSE-RANGING STUDY
Amin, Neeta
Carvajal-Gonzalez, Santos
Aggarwal, Naresh
Tuthill, Theresa
Inglot, Malgorzata
Bergman, Arthur
Esler, William
HEPATOLOGY, 2019, 70 : 21A - 22A
[36] TLC-3595, a selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, improves steatosis and fibrosis in murine models of NASH via pleiotropic mechanisms
Vijayakumar, Archana
Murakami, Eisuke
Huss, Ryan
Sroda, Natalie
Shimazaki, Atsuyuki
Morita, Ippei
Kato, Hideaki
Nakai, Manami
Ohyabu, Naoki
Subramanian, Mani
Myers, Robert
JOURNAL OF HEPATOLOGY, 2023, 78 : S323 - S323
[37] Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study
Amin, Neeta B.
Darekar, Amanda
Anstee, Quentin M.
Wong, Vincent Wai-Sun
Tacke, Frank
Vourvahis, Manoli
Lee, Douglas S.
Charlton, Michael
Alkhouri, Naim
Nakajima, Atsushi
Yunis, Carla
BMJ OPEN, 2022, 12 (03): : e056159

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