The role of T cells in the development of Henoch-Schonlein purpura

被引：6
|
作者：
Li, Yanlin [1 ,2 ]
Zhou, Yiping [1 ,2 ]
Zhu, Diqing [1 ,2 ]
Wang, Yongqing [1 ,2 ]
机构：
[1] Soochow Univ, People Hosp Changzhou 1, Dept Pediat, Changzhou 213000, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 3, Changzhou 213000, Jiangsu, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷
关键词：
Henoch-Schonlein purpura; CD4(+) T cells; Differentiation; Cytokines; Transcription Factors; Review; FOLLICULAR-HELPER-CELLS; TRANSCRIPTION FACTOR GATA-3; RHEUMATOLOGY; 1990; CRITERIA; BLOOD MONONUCLEAR-CELLS; DEVELOPING TH1 CELLS; ROR-GAMMA-T; IMMUNE-RESPONSES; IGA NEPHROPATHY; TGF-BETA; CONSENSUS CONFERENCE;
D O I：
10.2741/4619
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Henoch-Schonlein purpura (HSP) is an IgA-mediated disorder that most commonly occurs in children. Its etiology and pathogenesis remain unknown. In recent years, numerous studies have pointed to a dysfunction of T cells in the pathogenesis of HSP. Here, we will review the epidemiology, clinical and molecular characteristics of HSP, as well as abnormalities of Th cell subsets in this disorder. Finally, we will discuss the key factors that are involved in Th cell differentiation as potential novel targets for the prevention and treatment of HSP.
引用
收藏
页码：837 / 851
页数：15
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