A dual role of p21 in stem cell aging

被引：62
|
作者：
Ju, Zhenyu [1 ]
Choudhury, Aaheli Roy [1 ]
Rudolph, K. Lenhard [1 ]
机构：
[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endrocrinol, D-30625 Hannover, Germany
来源：
BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS | 2007年 / 1100卷
关键词：
aging; p21; stem cells; telomeres;
D O I：
10.1196/annals.1395.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A decline in adult stem cell function occurs during aging, likely contributing to the decline in organ homeostasis and regeneration with age. An emerging field in aging research is to analyze molecular pathways limiting adult stem cell function in response to macromolecular damage accumulation during aging. Current data suggest that the p21 cell cycle inhibitor has a dual role in stem cell aging: On one hand, p21 protects adult stem cells from acute genotoxic stress by preventing inappropriate cycling of acutely damaged stem cells. On the other hand, p21 activation impairs stem cell function and survival of aging telomere dysfunctional mice indicating that p21 checkpoint function is disadvantageous in the context of chronic and persistent damage, which accumulates during aging. This article focuses on these dual roles of p21 in aging stem cells.
引用
收藏
页码：333 / 344
页数：12
相关论文
共 50 条
  • [21] Role of eNOS, p21 and p53 in vascular smooth muscle cell proliferation.
    D'Souza, FM
    Kadowitz, PJ
    Sparks, RL
    Jeter, JR
    FASEB JOURNAL, 2000, 14 (04): : A407 - A407
  • [22] Plasma and urinary p21: potential biomarkers of AKI and renal aging
    Johnson, Ali C.
    Zager, Richard A.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2018, 315 (05) : F1329 - F1335
  • [23] The Role of p21 and p53 Proteins in Congenital Cholesteatoma
    Olszewska, Ewa
    Rutkowska, Justyna
    Minovi, Amir
    Sieskiewicz, Andrzej
    Rogowski, Marek
    Dazert, Stefan
    OTOLOGY & NEUROTOLOGY, 2013, 34 (02) : 266 - 274
  • [24] Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression
    Jung, Misun
    Kim, Wonyoung
    Cho, Jin Won
    Yang, Won Ho
    Chung, In Kwon
    BIOCHEMICAL JOURNAL, 2022, 479 (22) : 2379 - 2394
  • [25] Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells
    Kim, Heeyeon
    Kim, Haein
    Jang, Eunjung
    Eom, Young-Woo
    Yoon, Gyesoon
    Choi, Kyeong Sook
    Kim, Eunhee
    CELL DEATH DISCOVERY, 2025, 11 (01)
  • [26] CELL CYCLE - P21 INHIBITS CYCLIN SHOCK
    PINES, J
    NATURE, 1994, 369 (6481) : 520 - 521
  • [27] Hematopoietic stem cell expansion by HOXB4 is greatly enhanced in p21 deficient stem cells.
    Miyake, N
    Brun, ACM
    Magnusson, M
    Scadden, DT
    Karlsson, S
    BLOOD, 2004, 104 (11) : 469A - 470A
  • [28] Is p21 an oncogene?
    Gartel, Andrei L.
    MOLECULAR CANCER THERAPEUTICS, 2006, 5 (06) : 1385 - 1386
  • [29] Entamoeba histolytica: Isoprenylation of p21(ras) and p21(rap) in vitro
    Shen, PS
    Sanford, JC
    Samuelson, J
    EXPERIMENTAL PARASITOLOGY, 1996, 82 (01) : 65 - 68
  • [30] p21 and Paf as targets of E47 in regulating hematopoietic stem cell (HSC) function
    Santos, Patricia
    Borghesi, Lisa
    JOURNAL OF IMMUNOLOGY, 2012, 188
12345