A dual role of p21 in stem cell aging

被引：62
|
作者：
Ju, Zhenyu [1 ]
Choudhury, Aaheli Roy [1 ]
Rudolph, K. Lenhard [1 ]
机构：
[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endrocrinol, D-30625 Hannover, Germany
来源：
BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS | 2007年 / 1100卷
关键词：
aging; p21; stem cells; telomeres;
D O I：
10.1196/annals.1395.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A decline in adult stem cell function occurs during aging, likely contributing to the decline in organ homeostasis and regeneration with age. An emerging field in aging research is to analyze molecular pathways limiting adult stem cell function in response to macromolecular damage accumulation during aging. Current data suggest that the p21 cell cycle inhibitor has a dual role in stem cell aging: On one hand, p21 protects adult stem cells from acute genotoxic stress by preventing inappropriate cycling of acutely damaged stem cells. On the other hand, p21 activation impairs stem cell function and survival of aging telomere dysfunctional mice indicating that p21 checkpoint function is disadvantageous in the context of chronic and persistent damage, which accumulates during aging. This article focuses on these dual roles of p21 in aging stem cells.
引用
收藏
页码：333 / 344
页数：12
相关论文
共 50 条
  • [1] A limited role for p21 in maintaining normal hematopoietic stem cell functioning
    van Os, R.
    Kamminga, L. M.
    Ausema, A.
    Bystrykh, L.
    Draijer, D.
    Dontje, B.
    de Haan, G.
    EXPERIMENTAL HEMATOLOGY, 2006, 34 (09) : 42 - 42
  • [2] Dual Role of p21 in the Progression of Cancer and Its Treatment
    Parveen, Amna
    Akash, Muhammad Sajid Hamid
    Rehman, Kanwal
    Kyunn, Whang Wan
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2016, 26 (01): : 49 - 62
  • [3] The role of p21 in cellular senescence and aging-related diseases
    Yan, Jiayu
    Chen, Siyi
    Yi, Zimei
    Zhao, Ruowen
    Zhu, Jiayu
    Ding, Shuwen
    Wu, Junhua
    MOLECULES AND CELLS, 2024, 47 (11)
  • [4] The anti-aging promise of p21
    Papismadov, Nurit
    Gal, Hilah
    Krizhanovsky, Valery
    CELL CYCLE, 2017, 16 (21) : 1997 - 1998
  • [5] The Role of p21 in Pituitary Development
    Monahan, Pamela
    Raetzman, Lori T.
    BIOLOGY OF REPRODUCTION, 2009, : 183 - 184
  • [6] Telomeres, p21 and the cancer-aging hypothesis
    Jessica F Bell
    Norman E Sharpless
    Nature Genetics, 2007, 39 : 11 - 12
  • [7] Telomeres, p21 and the cancer-aging hypothesis
    Bell, Jessica F.
    Sharpless, Norman E.
    NATURE GENETICS, 2007, 39 (01) : 11 - 12
  • [8] Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
    Hyenjong Hong
    Kazutoshi Takahashi
    Tomoko Ichisaka
    Takashi Aoi
    Osami Kanagawa
    Masato Nakagawa
    Keisuke Okita
    Shinya Yamanaka
    Nature, 2009, 460 : 1132 - 1135
  • [9] Accelerating Stem Cell Proliferation by Down-Regulation of Cell Cycle Regulator p21
    Plasilova, Magdalena
    Schonmyer, Bjorn
    Fernandez, John
    Clavin, Nicholas
    Soares, Mark
    Mehrara, Babak J.
    PLASTIC AND RECONSTRUCTIVE SURGERY, 2009, 123 (02) : 149S - 157S
  • [10] The role of p21 in regulating mammalian regeneration
    Larry Matthew Arthur
    Ellen Heber-Katz
    Stem Cell Research & Therapy, 2
12345