The use of 5-alpha-reductase inhibitors for the prevention of prostate cancer

被引：0
|
作者：
Yu, Eun-mi [1 ]
El-Ayass, Walid [1 ]
Aragon-Ching, Jeanny B. [1 ]
机构：
[1] Washington Univ, Dept Med, Div Hematol & Oncol, Med Ctr, Washington, DC USA
来源：
CANCER BIOLOGY & THERAPY | 2010年 / 10卷 / 01期
关键词：
5-alpha-reductase inhibitors; finasteride; dutasteride; prostate cancer; FINASTERIDE;
D O I：
10.4161/cbt.10.1.12368
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The use of 5-alpha-reductase inhibitors has been studied not only in benign prostatic hyperplasia, but as a chemopreventive strategy in prostate cancer. Both finasteride and dutasteride, 5-alpha-reductase inhibitors (SARI), have been shown to decrease the risk for prostate cancer. The results of the REDUCE trial using the dual alpha-reductase isoenzyme inhibitor dutasteride, has recently been published by Andriole et al. in the New England Journal of Medicine. Certain considerations regarding its use and applicability to men with high risk of developing prostate cancer are herein discussed.
引用
收藏
页码：11 / 12
页数：2
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