Systems analysis of the prostate transcriptome in African-American men compared with European-American men

被引：59

作者：

Hardiman, Gary ^{[1
,2
]}

Savage, Stephen J. ^{[4
,5
]}

Hazard, E. Starr ^{[2
,3
]}

Wilson, Robert C. ^{[2
,6
]}

Courtney, Sean M. ^{[2
]}

Smith, Michael T. ^{[6
]}

Hollis, Bruce W. ^{[7
]}

Halbert, Chanita Hughes ^{[5
,8
]}

Gattoni-Celli, Sebastiano ^{[5
,9
]}

机构：

[1] Med Univ South Carolina, Dept Med & Publ Hlth, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Ctr Genom Med, Charleston, SC 29425 USA

[3] Med Univ South Carolina, Lib Sci & Informat, Charleston, SC USA

[4] Ralph H Johnson VA Med Ctr, Dept Urol, Charleston, SC USA

[5] Ralph H Johnson VA Med Ctr, Charleston, SC USA

[6] Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC USA

[7] Med Univ South Carolina, Dept Pediat, Charleston, SC USA

[8] Med Univ South Carolina, Dept Psychiat & Behav Sci, Charleston, SC USA

[9] Med Univ South Carolina, Dept Radiat Oncol, Charleston, SC 29425 USA

来源：

PHARMACOGENOMICS | 2016年 / 17卷 / 10期

关键词：

African-American; health disparities; prostate; RNA-seq; transcription; vitamin D; VITAMIN-D-RECEPTOR; DIFFERENTIAL EXPRESSION ANALYSIS; 1,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D; CANCER; SUPPLEMENTATION; RISK; GENE; PREDICTOR; BIOPSY;

D O I：

10.2217/pgs-2016-0025

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D-3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D-3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D-3 supplementation.

引用

页码：1129 / 1143

页数：15

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