Total synthesis of the dolabellane marine diterpenoids, claenone, palominol and dolabellatrienone

被引：21
|
作者：
Miyaoka, H [1 ]
Isaji, Y [1 ]
Mitome, H [1 ]
Yamada, Y [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan
来源：
TETRAHEDRON | 2003年 / 59卷 / 01期
关键词：
antitumour compounds; marine metabolites; terpenes and terpenoids;
D O I：
10.1016/S0040-4020(02)01474-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of marine dolabellane diterpenoids claenone, palominol and dolabellatrienone was conducted from D-mannitol. In each case, formation of the bicyclo[2.2.1]heptane derivative by sequential Michael reaction, preparation of the tetrasubstituted cyclopentane derivative by retro-aldol reaction and cyclization of sulfone were involved as key steps. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：61 / 75
页数：15
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