Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents

被引：0

作者：

El-serwy, Walaa S. ^{[1
]}

Mohamed, Neama A. ^{[1
]}

Kassem, Emad M. M. ^{[1
]}

Mahmoud, Khaled ^{[2
]}

Mounier, M. M. ^{[2
]}

机构：

[1] Natl Res Ctr, Therapeut Chem Dept, Cairo, Egypt

[2] Natl Res Ctr, Dept Pharmacognosy, Cairo, Egypt

来源：

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2016年 / 15卷 / 01期

关键词：

Cytotoxic activity; Benzoxazin; Quinazolin; Antitumor; Docking analysis; THYMIDYLATE SYNTHASE INHIBITORS; POTENT; ACID; CYTOTOXICITY; RECEPTOR; ANALOGS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against human carcinoma cell lines (HePG2-MCF7-A549). The docking and the cytotoxic activity results revealed that nearly all of the compounds containing N-phenyl aniline showed significant inhibition for the three cell lines.

引用

页码：179 / 196

页数：18

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