Serum zinc levels and Alzheimer's disease

被引：54
|
作者：
Rulon, LL
Robertson, JD [1 ]
Lovell, MA
Deibel, MA
Ehmann, WD
Markesbery, WR
机构：
[1] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
[2] Univ Kentucky, Dept Pathol, Lexington, KY 40506 USA
[3] Univ Kentucky, Dept Neurol, Lexington, KY 40506 USA
[4] Univ Kentucky, Sanders Brown Ctr Aging, Ctr Med, Lexington, KY 40536 USA
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2000年 / 75卷 / 1-3期
关键词：
zinc; serum; brain; Alzheimer's disease; FAAS; INAA;
D O I：
10.1385/BTER:75:1-3:79
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4 +/- 66.8 mu g/dL) compared with age-matched control subjects (71.1 +/- 35.0 mu g/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.
引用
收藏
页码：79 / 85
页数：7
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