Decreased serum zinc is an effect of ageing and not Alzheimer's disease

被引：33
|
作者：
Rembach, Alan [1 ]
Hare, Dominic J. [1 ,2 ]
Doecke, James D. [3 ,4 ]
Burnham, Samantha C. [3 ]
Volitakis, Irene [1 ]
Fowler, Christopher J. [1 ]
Cherny, Robert A. [1 ]
McLean, Catriona [5 ]
Grimm, Rudolf [6 ]
Martins, Ralph [7 ]
Ames, David [8 ]
Masters, Colin L. [1 ]
Bush, Ashley I. [1 ]
Roberts, Blaine R. [1 ]
机构：
[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia
[2] Univ Technol Sydney, Elemental Bioimaging Ctr, Sydney, NSW 2007, Australia
[3] CSIRO Preventat Hlth Flagship Math Informat & Sta, Perth, WA, Australia
[4] Australian E Hlth Res Ctr, Herston, Qld, Australia
[5] Alfred Hosp, Melbourne, Vic, Australia
[6] Agilent Technol, Santa Clara, CA USA
[7] Hlth Dept Western Australia, James McCusker Alzheimers Dis Res Unit, Osborne Pk, WA, Australia
[8] Natl Ageing Res Inst, Parkville, Vic, Australia
来源：
METALLOMICS | 2014年 / 6卷 / 07期
关键词：
TRANSCRIPTION FACTOR-I; OXIDATIVE STRESS; BINDING-ACTIVITY; TRACE-ELEMENT; DNA-BINDING; COPPER; METALS; AGGREGATION; DEFICIENCY; ALUMINUM;
D O I：
10.1039/c4mt00060a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.
引用
收藏
页码：1216 / 1219
页数：4
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