APD371, a peripherally restricted, highly selective, full agonist of the Cannabinoid Receptor 2 (CB2), reduces colitis-induced visceral hypersensitivity in rats

被引：0
|
作者：
Brierley, S. [1 ]
Castro, J. [1 ]
Maddern, J. [1 ]
Garcia-Caraballo, S. [1 ]
Lindstrom, B. [2 ]
Adams, J. [2 ]
机构：
[1] Flinders Univ S Australia, Adelaide, SA, Australia
[2] Arena Pharmaceut Inc, San Diego, CA USA
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2018年 / 30卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
042
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Ligand-steered modeling of the cannabinoid receptor 2: Successful applications to rationalize SAR data of selective CB2 inverse agonist and agonist compounds
    Phatak, Sharangdhar S.
    Diaz, Philippe
    Xu, Jijun
    Astruc-Diaz, Fanny
    Naguib, Mohammed
    Cavasotto, Claudio N.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [32] Effects of WIN 55,212-2, a cannabinoid CB1 and CB2 receptor agonist on food intake and body weight in rats with cisplatin induced anorexia
    Rutkowska, Maria
    Piesniewska, Matgorzata
    PHARMACOLOGICAL REPORTS, 2007, 59 : 93 - 94
  • [33] Highly selective CB2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice
    M. Salaga
    H. Zatorski
    M. Zielińska
    P. Mosinska
    J-P. Timmermans
    R. Kordek
    M. Storr
    J. Fichna
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2017, 390 : 1015 - 1027
  • [34] Highly selective CB2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice
    Salaga, M.
    Zatorski, H.
    Zielinska, M.
    Mosinska, P.
    Timmermans, J-P.
    Kordek, R.
    Storr, M.
    Fichna, J.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2017, 390 (10) : 1015 - 1027
  • [35] Selective long-term activation of cannabinoid CB2 receptors reduces hepatic fibrosis in cirrhotic rats with ascites
    Munyoz-Luque, J.
    Ros, J.
    Fernandez-Varo, G.
    Tugues, S.
    Morales-Ruiz, M.
    Alvarez, C. L.
    Friedman, S. L.
    Jimenez, W.
    JOURNAL OF HEPATOLOGY, 2007, 46 : S84 - S85
  • [36] Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis
    Freeman-Anderson, Natalie E.
    Pickle, Theresa G.
    Netherland, Courtney D.
    Bales, Alicia
    Buckley, Nancy E.
    Thewke, Douglas P.
    JOURNAL OF LIPID RESEARCH, 2008, 49 (11) : 2338 - 2346
  • [37] Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2:: Implication for intracellular signalization cross-regulation.
    Bouaboula, M
    Desnoyer, N
    Carayon, P
    Combes, T
    Casellas, P
    MOLECULAR PHARMACOLOGY, 1999, 55 (03) : 473 - 480
  • [38] The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats
    de Carvalho, Cristiane R.
    Hoeller, Alexandre A.
    Franco, Pedro L. C.
    Martini, Athos P. S.
    Soares, Flavia M. S.
    Lin, Katia
    Prediger, Rui D.
    Whalley, Benjamin J.
    Walz, Roger
    EPILEPSY RESEARCH, 2016, 127 : 160 - 167
  • [39] A selective cannabinoid CB2 receptor agonist decreases infarct volume in a mouse middle cerebral artery occlusion/reperfusion model
    Zhang, M
    Martin, BR
    Baron, E
    Adler, MW
    Jallo, J
    Tuma, RF
    FASEB JOURNAL, 2006, 20 (05): : A1157 - A1157
  • [40] Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
    Capozzi, Antonella
    Caissutti, Daniela
    Mattei, Vincenzo
    Gado, Francesca
    Martellucci, Stefano
    Longo, Agostina
    Recalchi, Serena
    Manganelli, Valeria
    Riitano, Gloria
    Garofalo, Tina
    Sorice, Maurizio
    Manera, Clementina
    Misasi, Roberta
    MOLECULES, 2022, 27 (01):
12345