APD371, a peripherally restricted, highly selective, full agonist of the Cannabinoid Receptor 2 (CB2), reduces colitis-induced visceral hypersensitivity in rats

被引：0
|
作者：
Brierley, S. [1 ]
Castro, J. [1 ]
Maddern, J. [1 ]
Garcia-Caraballo, S. [1 ]
Lindstrom, B. [2 ]
Adams, J. [2 ]
机构：
[1] Flinders Univ S Australia, Adelaide, SA, Australia
[2] Arena Pharmaceut Inc, San Diego, CA USA
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2018年 / 30卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
042
引用
收藏
页数：2
相关论文
共 50 条
  • [1] OLORINAB (FORMERLY APD371), A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB2), REDUCES VISCERAL HYPERSENSITIVITY IN ANIMAL MODELS
    Castro, Joel
    Maddern, Jessica
    Garcia-Caraballo, Sonia
    Lumsden, Amanda L.
    Lindstrom, Beatriz
    Adams, John
    Brierley, Stuart
    GASTROENTEROLOGY, 2019, 156 (06) : S382 - S382
  • [2] Olorinab (APD371), a peripherally restricted, highly selective, full agonist of the cannabinoid receptor type 2 (CB2), reduces visceral hypersensitivity in animal models
    Castro, J.
    Maddern, J.
    Garcia-Caraballo, S.
    Lumsden, A.
    Lindstrom, B.
    Adams, J.
    Brierley, S. M.
    NEUROGASTROENTEROLOGY AND MOTILITY, 2019, 31
  • [3] Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents
    Castro, Joel
    Garcia-Caraballo, Sonia
    Maddern, Jessica
    Schober, Gudrun
    Lumsden, Amanda
    Harrington, Andrea
    Schmiel, Shirdi
    Lindstrom, Beatriz
    Adams, John
    Brierley, Stuart M.
    PAIN, 2022, 163 (01) : E72 - E86
  • [4] Olorinab, a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2 (CB2), reduces visceral hypersensitivity in mice
    Castro, Joel
    Maddern, Jessica
    Garcia-Caraballo, Sonia
    Schober, Gudrun
    Lindstrom, Beatriz
    Schmiel, Shirdi
    Brierley, Stuart M.
    NEUROGASTROENTEROLOGY AND MOTILITY, 2020, 32
  • [5] PHARMACOKINETICS (PK) AND SAFETY OF OLORINAB (APD371), A HIGHLY SELECTIVE, PERIPHERALLY ACTING FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB2), IN HEALTHY ADULT SUBJECTS.
    Stauber, K.
    Oh, D.
    Tang, Y.
    Lindstrom, B.
    English, B.
    Cabell, C.
    Ruckle, J.
    Searle, S.
    Kam, J.
    Jones, R.
    Grundy, J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020, 107 : S79 - S79
  • [6] CANNABINOID RECEPTOR EXPRESSION AND THE EFFECT OF OLORINAB, A PERIPHERALLY ACTING, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB2), IN RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY
    Castro, Joel
    Maddern, Jessica
    Garcia-Caraballo, Sonia
    Schober, Gudrun
    Lindstrom, Beatriz
    Schmiel, Shirdi
    Brierley, Stuart
    GASTROENTEROLOGY, 2020, 158 (06) : S269 - S269
  • [7] Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain
    Han, Sangdon
    Thoresen, Lars
    Jung, Jae-Kyu
    Zhu, Xiuwen
    Thatte, Jayant
    Solomon, Michelle
    Gaidarov, Ibragim
    Unett, David J.
    Yoon, Woo Hyun
    Barden, Jeremy
    Sadeque, Abu
    Usmani, Amin
    Chen, Chuan
    Semple, Graeme
    Grottick, Andrew J.
    Al-Shamma, Hussein
    Christopher, Ronald
    Jones, Robert M.
    ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (12): : 1309 - 1313
  • [8] The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity
    Mukhopadhyay, Partha
    Baggelaar, Marc
    Erdelyi, Katalin
    Cao, Zongxian
    Cinar, Resat
    Fezza, Filomena
    Ignatowska-Janlowska, Bogna
    Wilkerson, Jenny
    van Gils, Noortje
    Hansen, Thomas
    Ruben, Marc
    Soethoudt, Marjolein
    Heitman, Laura
    Kunos, George
    Maccarrone, Mauro
    Lichtman, Aron
    Pacher, Pal
    Van der Stelt, Mario
    BRITISH JOURNAL OF PHARMACOLOGY, 2016, 173 (03) : 446 - 458
  • [9] A combination of peripherally restricted CB1 and CB2 cannabinoid receptor agonists reduces bladder afferent sensitisation in cystitis
    Ramsay, Stewart
    Yew, Wai Ping
    Brookes, Simon
    Zagorodnyuk, Vladimir
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2024, 985
  • [10] Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis
    El Bakali, Jamal
    Muccioli, Giulio G.
    Body-Malapel, Mathilde
    Djouina, Madjid
    Klupsch, Frederique
    Ghinet, Alina
    Barczyk, Amelie
    Renault, Nicolas
    Chavatte, Philippe
    Desreumaux, Pierre
    Lambert, Didier M.
    Millet, Regis
    ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (02): : 198 - 203
12345