Cytotoxicity of nanostructured vanadium oxide on human cells in vitro

被引：23
|
作者：
Rhoads, Laura S. [1 ]
Silkworth, William T. [1 ]
Roppolo, Megan L. [2 ,3 ]
Whittingham, M. Stanley [2 ,3 ]
机构：
[1] SUNY Coll Potsdam, Dept Biol, Potsdam, NY 13676 USA
[2] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA
[3] SUNY Binghamton, Inst Mat Res, Binghamton, NY 13902 USA
来源：
TOXICOLOGY IN VITRO | 2010年 / 24卷 / 01期
基金：
美国国家科学基金会;
关键词：
Nanoparticle; Vanadium oxide; Neutral red assay; Cytotoxicity; Caco-2; cells; NANOPARTICLES; TOXICITY; MODEL; LINE; TRANSPORT; CACO-2;
D O I：
10.1016/j.tiv.2009.08.010
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Vanadium oxide nanostructures have potential uses for electrochemistry and catalysis, yet little is known about their toxicology. In this study, Cultured human colon carcinoma cells (Caco-2) were exposed to vanadium oxide and their viability assessed with the neutral red assay. Cells exposed to either vanadium oxide (powdered form) or ethylene diamine intercalated vanadium oxide (enH(2))V7O16 demonstrated no significant reduction in viability after twenty-four hours, yet cells exposed to vanadium oxide nanotubes demonstrated a significant loss in viability after four hours. The physical size and structure of the nanotubes may play an important role in their cytotoxic effects, and the safety of using such nanomaterials must be considered. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：292 / 296
页数：5
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