NDM-12, a Novel New Delhi Metallo-β-Lactamase Variant from a Carbapenem-Resistant Escherichia coli Clinical Isolate in Nepal

被引：31

作者：

Tada, Tatsuya ^{[1
]}

Shrestha, Basudha

Miyoshi-Akiyama, Tohru ^{[1
]}

Shimada, Kayo ^{[1
]}

Ohara, Hiroshi ^{[2
]}

Kirikae, Teruo ^{[1
]}

Pokhrel, Bharat M. ^{[3
]}

机构：

[1] Natl Ctr Global Hlth & Med, Dept Infect Dis, Res Inst, Shinjuku Ku, Tokyo, Japan

[2] Natl Ctr Global Hlth & Med, Dept Int Med Cooperat, Shinjuku Ku, Tokyo, Japan

[3] Tribhuvan Univ, Inst Med, Dept Microbiol, Kathmandu, Nepal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 10期

关键词：

ACINETOBACTER-BAUMANNII; PSEUDOMONAS-AERUGINOSA; MOLECULAR CHARACTERIZATION; BIOCHEMICAL-CHARACTERIZATION; SERRATIA-MARCESCENS; CRYSTAL-STRUCTURE; MULTIPLEX PCR; GENE; INTEGRON; SUBCLASS;

D O I：

10.1128/AAC.03355-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel New Delhi metallo-beta-lactamase variant, NDM-12, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from a urine sample from a patient in Nepal. NDM-12 differed from NDM-1 by two amino acid substitutions (M154L and G222D). The enzymatic activities of NDM-12 against beta-lactams were similar to those of NDM-1, although NDM-12 showed lower k(cat)/K-m ratios for all beta-lactams tested except doripenem. The bla(NDM-12) gene was located in a plasmid of 160 kb.

引用

页码：6302 / 6305

页数：4

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