Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells

被引：18

作者：

Pang, Xu ^{[1
,2
]}

Yin, Shuang-Shuang ^{[1
]}

Yu, Hai-Yang ^{[1
,2
]}

Zhang, Yi ^{[1
,2
]}

Wang, Tao ^{[1
,2
]}

Hu, Li-Min ^{[1
]}

Han, Li-Feng ^{[1
,2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Epimedium brevicornu; prenylated flavonoid; dihydrophenanthrene; HepG2; cells; cytotoxicity; CANCER CELLS; PATHWAY; CONSTITUENTS; APOPTOSIS; GROWTH;

D O I：

10.1080/14786419.2017.1405410

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical study on the leaves of Epimedium brevicornu finally led to the isolation of four prenylated flavonoids (1-4) and three dihydrophenanthrenes (5-7), of which 1, 2, 5 and 7 were new compounds. The structures of these compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry. These isolates exhibited the cytotoxic activities against HepG2 cells with the IC50 values of 32.8-87.3M. [GRAPHICS] .

引用

页码：2253 / 2259

页数：7

共 50 条

[31] Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells
Chen, Hong-Ying
Ye, Xiao-Li
Cui, Xue-Long
He, Kai
Jin, Ya-Nan
Chen, Zhu
Li, Xue-Gang
FITOTERAPIA, 2012, 83 (01) : 67 - 73
[32] Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines
Decharchoochart, Phatharapoll
Suthiwong, Jittra
Samatiwat, Papavee
Kukongviriyapan, Veerapol
Yenjai, Chavi
JOURNAL OF NATURAL MEDICINES, 2014, 68 (04) : 730 - 736
[33] Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines
Phatharapoll Decharchoochart
Jittra Suthiwong
Papavee Samatiwat
Veerapol Kukongviriyapan
Chavi Yenjai
Journal of Natural Medicines, 2014, 68 : 730 - 736
[34] Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia
Jittra Suthiwong
Jaroon Wandee
Siripit Pitchuanchom
Punchapat Sojikul
Veerapol Kukongviriyapan
Chavi Yenjai
Medicinal Chemistry Research, 2018, 27 : 2042 - 2049
[35] Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia
Suthiwong, Jittra
Wandee, Jaroon
Pitchuanchom, Siripit
Sojikul, Punchapat
Kukongviriyapan, Veerapol
Yenjai, Chavi
MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (08) : 2042 - 2049
[36] Enzymatic defense of HepG2 cells against cytotoxicity induced by T-2 and its modified forms
Taroncher, M.
Rodriguez-Carrasco, Y.
Ruiz, M. J.
TOXICOLOGY LETTERS, 2021, 350 : S106 - S106
[37] Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells
Szuster-Ciesielska, A
Kandefer-Szerszen, M
PHARMACOLOGICAL REPORTS, 2005, 57 (05) : 588 - 595
[38] In Vitro Cytotoxicity of Magnetic Spinel Nanoferrites (CoMgFe2O4) Against HepG2 Cells
Aziz, Muhammad Hammad
Fatima, Mahvish
Ali, Syed Mansoor
Atif, M.
Noreen, Zobia
Ahmad, Imran
Shaheen, Fozia
Ali, Akbar
Baig, M. R.
Ullah, Hafeez
Abbas, Ghazanfar
ALkhuraiji, Turki S.
JOURNAL OF NANOELECTRONICS AND OPTOELECTRONICS, 2018, 13 (02) : 251 - 257
[39] Atorvastatin-TPGS-PLGA Nanoparticles Cytotoxicity Augmentation Against Liver Cancer HepG2 cells
Alfaifi, Mohammad Y.
Shati, Ali A.
Alshehri, Mohammed Ali
Elbehairi, Serag Eldin, I
Fahmy, Usama A.
Alshehri, Ohoud Yahya
INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2020, 16 (02) : 79 - 86
[40] The Hepatoprotective Effects of Moringa oleifera against Antiretroviral-Induced Cytotoxicity in HepG2 Cells: A Review
Saki, Mbasakazi
De Villiers, Helena
Ntsapi, Claudia
Tiloke, Charlette
PLANTS-BASEL, 2023, 12 (18):

← 1 2 3 4 5 →