Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells

被引：18

作者：

Pang, Xu ^{[1
,2
]}

Yin, Shuang-Shuang ^{[1
]}

Yu, Hai-Yang ^{[1
,2
]}

Zhang, Yi ^{[1
,2
]}

Wang, Tao ^{[1
,2
]}

Hu, Li-Min ^{[1
]}

Han, Li-Feng ^{[1
,2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Epimedium brevicornu; prenylated flavonoid; dihydrophenanthrene; HepG2; cells; cytotoxicity; CANCER CELLS; PATHWAY; CONSTITUENTS; APOPTOSIS; GROWTH;

D O I：

10.1080/14786419.2017.1405410

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical study on the leaves of Epimedium brevicornu finally led to the isolation of four prenylated flavonoids (1-4) and three dihydrophenanthrenes (5-7), of which 1, 2, 5 and 7 were new compounds. The structures of these compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry. These isolates exhibited the cytotoxic activities against HepG2 cells with the IC50 values of 32.8-87.3M. [GRAPHICS] .

引用

页码：2253 / 2259

页数：7

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