Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics

被引:105
|
作者
Kim, S
Lee, SW
Choi, EC
Choi, SY
机构
[1] Seoul Natl Univ, Coll Pharm, Natl Creat Res Initiat Ctr ARS Network, Kwanak Gu, Seoul 151742, South Korea
[2] Seoul Natl Univ, Imagene Co Ltd, Biotechnol Incubat Ctr, Kwanak Gu, Seoul 151742, South Korea
关键词
D O I
10.1007/s00253-003-1243-5
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The emergence of multidrug-resistant strains of pathogenic microorganisms and the slow progress in new antibiotic development has led in recent years to a resurgence of infectious diseases that threaten the wellbeing of humans. The result of many microorganisms becoming immune to major antibiotics means that fighting off infection by these pathogens is more difficult. The best strategy to get around drug resistance is to discover new drug targets, taking advantage of the abundant information that was recently obtained from genomic and proteomic research, and explore them for drug development. In this regard, aminoacyl-tRNA synthetases (ARSs) provide a promising platform to develop novel antibiotics that show no cross-resistance to other classical antibiotics. During the last few years there has been a comprehensive attempt to find the compounds that can specifically target ARSs and inhibit bacterial growth. In this review, the current status in the development of ARS inhibitors will be briefly summarized, based on their chemical structures and working mechanisms.
引用
收藏
页码:278 / 288
页数:11
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