A specific deletion pattern in the preS1-and preS2-domain is associated with treatment induced HBsAg loss in chronic hepatitis B

被引：0
|
作者：
Pfefferkorn, Maria [1 ]
Deichsel, Danilo [1 ]
Matz-Soja, Madlen [1 ,2 ]
Berg, Thomas [1 ]
van Boemmel, Florian [1 ]
机构：
[1] Univ Leipzig, Med Ctr, Dept Med 2, Div Hepatol, Leipzig, Germany
[2] Univ Leipzig, Fac Med, Rudolf Schonheimer Inst Biochem, Leipzig, Germany
来源：
JOURNAL OF HEPATOLOGY | 2021年 / 75卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
PO-2135
引用
收藏
页码：S706 / S706
页数：1
相关论文
共 50 条
  • [41] Selective targeting by preS1 domain of hepatitis B surface antigen conjugated with phosphorylcholine-based amphiphilic block copolymer micelles as a biocompatible, drug delivery carrier for treatment of human hepatocellular carcinoma with paclitaxel
    Miyata, Ryohei
    Ueda, Masakazu
    Jinno, Hiromitsu
    Konno, Tomohiro
    Ishihara, Kazuhiko
    Ando, Nobutoshi
    Kitagawa, Yuko
    INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (10) : 2460 - 2467
  • [42] Increased NK Cell Function After Cessation of Long-Term Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Is Associated With Liver Damage and HBsAg Loss
    Zimmer, Christine L.
    Rinker, Franziska
    zu Siederdissen, Christoph Hoener
    Manns, Michael P.
    Wedemeyer, Heiner
    Cornberg, Markus
    Bjorkstrom, Niklas K.
    JOURNAL OF INFECTIOUS DISEASES, 2018, 217 (10): : 1656 - 1666
  • [43] Model-based meta-analysis of pegylated IFN-alpha induced HBsAg loss at end of treatment and 24 weeks post treatment in chronic hepatitis B virus infection
    Hanan, Nathan
    Zierhut, Matthew L.
    Nader, Ahmed
    Mahajan, Anadi
    Kaur, Amandeep
    Kumar, Krishna
    Dixon, Susan
    Das, Joyeta
    Magee, Mindy
    Theodore, Dickens
    Gielen, Vera
    JOURNAL OF HEPATOLOGY, 2023, 78 : S1141 - S1142
  • [44] Genome wide association study of Chronic Hepatitis B patients identified a variation in the SLC16A9 gene which is associated with HBsAg loss after treatment with peginterferon and adefovir
    Jansen, Louis
    de Niet, Annikki
    van Iperen, Erik
    Takkenberg, Bart
    Chin, Daniel J.
    Zaaijer, Hans L.
    Kootstra, Neeltje A.
    Reesink, Hendrik W.
    HEPATOLOGY, 2012, 56 : 411A - 411A
  • [45] Baseline and early on-treatment HBsAg level to predict HBsAg loss in nucleotide analog suppressed and HBeAg cleared chronic hepatitis B patients by switching to peginterferon alfa-2a: exploratory results of NEW SWITCH study
    Hu, P.
    Xie, Q.
    Li, Y.
    Chen, X.
    Dou, X.
    Jiang, J.
    Shang, J.
    Zhang, W.
    Gong, G.
    Sun, Y.
    Li, Y.
    Liu, Y.
    Liu, G.
    Mao, D.
    Chi, X.
    Tang, H.
    Li, X.
    Xie, Y.
    Chen, X.
    Jiang, J.
    Zhao, P.
    Hou, J.
    Gao, Z.
    Fan, H.
    Ding, J.
    Ren, H.
    JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S265 - S265
  • [46] Soluble Programmed Cell Death-1 is a Novel Predictor of HBsAg Loss in Chronic Hepatitis B Patients When Long-Term Nucleos(t)ide Analog Treatment is Discontinued
    Liao, Guichan
    Liu, Ziying
    Xia, Muye
    Chen, Hongjie
    Wu, Houji
    Li, Bing
    Yu, Tao
    Cai, Shaohang
    Zhang, Xiaoyong
    Peng, Jie
    INFECTION AND DRUG RESISTANCE, 2022, 15 : 2347 - 2357
  • [47] The baseline combination of HBcrAg and HBsAg titers enhance treatment outcome and HBsAg loss predictions in HBeAg negative chronic hepatitis B patients treated with pegylated interferon alfa-2a or PegIFN plus Tenofovir-disoproxil-fumarate
    Martinot-Peignoux, Michelle
    Lapalus, Martine
    Boyer, Nathalie
    Castelnau, Corinne
    Giuily, Nathalie
    Pouteau, Michele
    Moucari, Rami
    Asselah, Tarik
    Marcellin, Patrick
    HEPATOLOGY, 2015, 62 : 1205A - 1205A
  • [48] A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation
    Jeong, Hyein
    Choi, Yu-Min
    Seo, Hyejun
    Kim, Bum-Joon
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [49] TRACKING B CELL IMMUNITY DURING PERTURBATION OF HEPATITIS B INFECTION INDUCED BY TREATMENT WITHDRAWAL WITHDRAWAL OF PROLONGED NUCLEOS( T) IDE ANALOGUE ( NA) TREATMENT CAN RESULT IN HBSAG LOSS IN SOME SUBJECTS WITH CHRONIC HEPATITIS B ( CHB), POTENTIALLY REVEALING IMMUNE CORRELATES OF FUNCTIONAL CURE. WE AIMED TO ASSESS WHETHER THERE WAS ANY RECOVERY OF DEFECTIVE HUMORAL IMMUNITY IN THOSE WITH LOSS OF HBSAG, WITH OR WITHOUT DEVELOPMENT OF ANTIHBS ANTIBODIES, IN THIS SETTING
    Lens, Sabela
    Burton, Alice
    Davies, Jessica
    Garcia-Lopez, Mireia
    Pocurull, Anna
    Novikov, Nikolai
    Fletcher, Simon
    Forns, Xavier
    Perez-Del-Pulgar, Sofia
    Maini, Mala
    HEPATOLOGY, 2024, 80 : S278 - S279
  • [50] Naturally occurring deletion/insertion mutations within HBV whole genome sequences in HBeAg-positive chronic hepatitis B patients are correlated with baseline serum HBsAg and HBeAg levels and might predict a shorter interval to HBeAg loss and seroconversion during antiviral treatment
    Hao, Ran
    Xiang, Kuanhui
    Peng, Yaqin
    Hou, Jinlin
    Sun, Jian
    Li, Yao
    Su, Mingze
    Yan, Ling
    Zhuang, Hui
    Li, Tong
    INFECTION GENETICS AND EVOLUTION, 2015, 33 : 261 - 268
12345