Self-Assembled Novel BODIPY-Based Palladium Supramolecules and Their Cellular Localization

被引：68

作者：

Gupta, Gajendra ^{[1
]}

Das, Abhishek ^{[3
]}

Park, Kyoung Chul ^{[1
]}

Tron, Artur ^{[1
]}

Kim, Hyunuk ^{[4
]}

Mun, Junyoung ^{[1
]}

Mandal, Nripendranath ^{[3
]}

Chi, Ki-Whan ^{[5
]}

Lee, Chang Yeon ^{[1
,2
]}

机构：

[1] Incheon Natl Univ, Dept Energy & Chem Engn, 119 Acad Ro, Incheon 22012, South Korea

[2] Incheon Natl Univ, Innovat Ctr Chem Engn, 119 Acad Ro, Incheon 22012, South Korea

[3] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, India

[4] Korea Inst Energy Res, Convergence Mat Lab, Daejeon 305343, South Korea

[5] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea

来源：

INORGANIC CHEMISTRY | 2017年 / 56卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

M2L4 COORDINATION CAPSULES; PHOTOPHYSICAL PROPERTIES; ANTICANCER ACTIVITY; DNA-BINDING; COMPLEXES; TRIANGLE; SQUARE; LIGAND; RU(II); INTERCONVERSION;

D O I：

10.1021/acs.inorgchem.7b00260

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Four new palladium metal supramolecules with triangular/square architectures derived from boron dipyrromethane (BODIPY) ligands were synthesized by self-assembly and fully characterized by H-1 and P-31 NMR, electrospray ionization mass spectrometry, and single-crystal X-ray diffraction. These supramolecules were more cytotoxic to brain cancer (glioblastoma) cells than to normal lung fibroblasts. Their cytotoxicity to the glioblastoma cells was higher than that of a benchmark metal-based chemotherapy drug, cisplatin. The characteristic green fluorescence of the BODIPY ligands in these supramolecules permitted their intracellular visualization using confocal microscopy, and the compounds were localized in the cytoplasm and on the plasma membrane.

引用

页码：4615 / 4621

页数：7

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