Synthesis of the novel thieno[4,3,2-ef][1,4]benzoxazepine ring system: 4,5-dihydro-3-(4-pyridinyl)thieno[4,3,2-ef][1,4]benzoxazepine maleate

被引：7

作者：

Tomer, JD ^{[1
]}

Shutske, GM ^{[1
]}

Friedrich, D ^{[1
]}

机构：

[1] Hoechst Mar Roussel Inc, Bridgewater, NJ 08807 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 06期

关键词：

D O I：

10.1002/jhet.5570340621

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4,5-Dihydro-3-(4-pyridinyl)-thieno[4,3,2-ef][1,4]benzoxazepine maleate 2 has been synthesized from 3-amino-4-fluorobenzo[b]thiophene by employing an intramolecular nucleophilic aromatic fluoride displacement. In the presence of strong base and heat, 2 rearranges to form the isomeric hemiaminal, 3,4-dihydro-4-methyl-3-(4-pyridinyl)thieno[4,3,2-de][1,3] benzoxazine 10. A proposed mechanism for this rearrangement is discussed.

引用

页码：1769 / 1772

页数：4

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