Chlamydia pneumoniae in atherosclerotic and nonatherosclerotic tissue

被引：26

作者：

Ouchi, K

Fujii, B

Kudo, S

Shirai, M

Yamashita, K

Gondo, T

Ishihara, T

Ito, H

Nakazawa, T

机构：

[1] Saiseikai Shimoneseki Gen Hosp, Dept Pediat, Shimonoseki, Yamaguchi 7518502, Japan

[2] Saiseikai Shimoneseki Gen Hosp, Dept Internal Med, Shimonoseki, Yamaguchi 7518502, Japan

[3] Chiba Prefecture, Publ Hlth Lab, Chiba, Japan

[4] Yamaguchi Univ, Sch Med, Dept Microbiol, Ube, Yamaguchi 755, Japan

[5] Yamaguchi Univ, Sch Med, Dept Neurosurg, Ube, Yamaguchi 755, Japan

[6] Yamaguchi Univ, Sch Med, Dept Pathol, Ube, Yamaguchi 755, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2000年 / 181卷

关键词：

D O I：

10.1086/315617

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The positivity rate and localization of Chlamydia pneumoniae were investigated in atherosclerotic and nonatherosclerotic tissues by immunohistochemistry, polymerase chain reaction, and cell culture. In total, 67 atheromatous plaques from Japanese symptomatic patients and 110 nonatherosclerotic tissues and organs were evaluated. Of these, 62% of atherosclerotic plaques from symptomatic patients were infected with C. pneumoniae compared with just 2% of nonatherosclerotic tissues. Immunohistochemically stained C. pneumoniae were found most often in smooth muscle cells, less often in macrophages, and in a few endothelial cells.

引用

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页码：S441 / S443

页数：3

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