Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid

被引:13
|
作者
Plotnikov, MB
Aliev, OI
Maslov, MJ
Vasiliev, AS
Tjukavkina, NA
机构
[1] Russian Acad Med Sci, Ctr Sci, Inst Pharmacol, Lab Blood Circulat Pharmacol, Tomsk 634028, Russia
[2] IM Sechenov Med Acad, Dept Organ Chem, Moscow 105043, Russia
关键词
diquertin; ascorbic acid; myocardial infarction; haemorheology;
D O I
10.1002/ptr.1082
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
In a model of the high blood viscosity syndrome, developed after myocardial infarction in rats, it was observed that a therapy of a combination of diquertin (20 mg/kg) and ascorbic acid (50 mg/kg) for a period of 6 days, resulted in an improvement of haemorheological indices. The decrease in blood viscosity was primarily due to an improved deformability of erythrocytes, and to some extent, due to a decrease in the content of plasma fibrinogen and erythrocyte aggregation. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:86 / 88
页数:3
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