An easy entry to (1S, 2S) and (1R, 2R)-threo-ifenprodil

被引：4
|
作者：
Mantegani, S [1 ]
Arlandini, E [1 ]
Brambilla, E [1 ]
Cremonesi, P [1 ]
Varasi, M [1 ]
机构：
[1] Pharmacia & Upjohn Inc, Dept Chem, Discovery Res Oncol, I-20014 Nerviano, MI, Italy
来源：
SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 19期
关键词：
D O I：
10.1080/00397910008087268
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.
引用
收藏
页码：3543 / 3553
页数：11
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