Topical anti-inflammatory activity of Solanum corymbiflorum leaves

Solanum corymbiflorum is popularly known as "baga-de-veado" and its leaves are applied on inflamed legs, scabies, tick bite, boils, mastitis, low back pain and otitis. The aim of this study was evaluate anti-inflammatory in vivo activity and relate this activity with antioxidant compounds present in the extract of S. corymbiflorum leaves. The extract from S. corymbiflorum leaves topically applied was able to reduce the croton oil-induced ear edema and myeloperoxidase (MPO) activity with maximum inhibition of 87 +/- 3% and 45 +/- 7%, rescpectively in the dose of 1 mg/ear. Similar results were found for positive control dexamethasone, which presented inhibitions of ear edema and MPO activity of 89 +/- 3% and 50 +/- 3%, respectively in a dose of 0.1 mg/ear. These findings are due, at least in part, the presence of polyphenols (195.28 mg GAE/g) and flavonoids, as chlorogenic acid (59.27 mg/g), rutin (12.72 mg/g), rosmarinic acid, caffeic acid and gallic acid found by high performance liquid chromatography (HPLC) analysis. This species showed potencial antioxidant by 1,1-diphenyl-2-picrylhydrazyl (DPPH), and carbonyl groups in proteins methods which may be related with the presence of this compounds. This species possess anti-inflammatory activity confirming their popular use for the local treatment of skin inflammatory disorders. (C) 2016 Elsevier Ireland Ltd. All rights reserved.