In-house phage amplification assay is a sound alternative for detecting rifampin-resistant Mycobacterium tuberculosis in low-resource settings

被引:23
|
作者
Símboli, N
Takiff, H
McNerney, R
López, B
Martin, A
Palomino, JC
Barrera, L
Ritacco, V
机构
[1] INEI ANLIS Carlos G Malbran, Serv Microbacterias, RA-1281 Buenos Aires, DF, Argentina
[2] INEI ANLIS Carlos G Malbran, Inst Nacl Enfermedades Infecciasas, RA-1281 Buenos Aires, DF, Argentina
[3] IVIC, Caracas, Venezuela
[4] London Sch Hyg & Trop Med, London WC1, England
[5] Inst Trop Med, Antwerp, Belgium
关键词
D O I
10.1128/AAC.49.1.425-427.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
An in-house myrobacteriophage amplification assay for detecting rifampin-resistant Mycobacterium tuberculosis showed 100% sensitivity, 97.7% specificity, and 95.2% predictive value for resistance in a test of 129 isolates from a hot spot area of multidrug-resistant M. tuberculosis. The applicability of the test was demonstrated in the routine work flow of a low-resource reference laboratory.
引用
收藏
页码:425 / 427
页数:3
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