Synthesis and free radical scavenging activity of some 1,3,4-thiadiazole derivatives

被引：0
|
作者：
Chhajed, M. R. [1 ]
Khedekar, P. B. [1 ]
Mundhey, A. S. [1 ]
机构：
[1] Sharad Pawar Coll Pharm, Nagpur 441110, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 16卷 / 03期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5-[(4-Acetamido) benzenesulphonamido]-1,3,4-thiadiazol-2-(N-benzoyl)sulphonamides (8a-g) were synthesized from 5-amino-1,3,4-thiadiazol-2-[N-(benzoyl) sulphonamides (4a-d) and 4-acetamidobenzenesulphonyl chlorides (7a). 5-[4-amino)]-benzenesulphonamido]-1,3,4-thiadiazol-2-[N-benzoyl] sulphonamides (9a-g) were obtained by hydrolysis of (8a-g) using 20% aq sodium hydroxide solution while, 5-(4-amino) benzenesulphonamido-1,3,4-thiadiazol-2-sulphonamides (10a-b) were obtained by hydrolysis of (9a-g) using 70% sulphuric acid respectively. Compounds were characterized by their analytical and spectral data. They were further screened for their in vitro free radical scavenging activity.
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页码：259 / 262
页数：4
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