Aberrant follicle development and anovulation in polycystic ovary syndrome

被引：28
|
作者：
Franks, S. [1 ]
Hardy, K. [1 ]
机构：
[1] Imperial Coll Sch Med, Hammersmith Hosp, Inst Reprod & Dev Biol, London W12 0NN, England
来源：
ANNALES D ENDOCRINOLOGIE | 2010年 / 71卷 / 03期
关键词：
Follicle; Anovulation; Polycystic ovary syndrome; IN-VITRO MATURATION; GRANULOSA-CELLS; OOCYTE QUALITY; WOMEN; GROWTH; INFERTILITY; MECHANISM; HORMONE;
D O I：
10.1016/j.ando.2010.02.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Endocrine factors appear to play an important part in arrest of antral follicle maturation in polycystic ovary syndrome (PCOS) but are unlikely to have an impact on early, preantral follicle development, which is clearly abnormal in PCOS. Disordered early folliculogenesis in PCOS is characterised by a higher proportion of follicles entering the growing phase and more prolonged survival of small follicles than in normal ovarian tissue. The factors responsible for aberrant preantral follicle development remain to be determined but IGFs, growth factors of the TGF beta family and androgens may all have a role. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：228 / 230
页数：3
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