Etiology of anovulation in polycystic ovary syndrome

被引：36

作者：

Franks, S ^{[1
]}

Mason, H ^{[1
]}

White, D ^{[1
]}

Willis, D ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Div Paediat Obstet & Gynaecol, Reprod Endocrinol Grp, London W2 1PG, England

来源：

STEROIDS | 1998年 / 63卷 / 5-6期

关键词：

polycystic ovary syndrome; anovulation; cyclic AMP; insulin; luteinizing hormone; androgens;

D O I：

10.1016/S0039-128X(98)00035-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various endocrine factors may contribute to the phenomenon of arrested follicular development, which is the hallmark of anovulatory infertility in polycystic ovary syndrome. Hypersecretion of luteinizing hormone and/or insulin, together with high intrafollicular concentrations of androgens, can interact to produce supraphysiological levels of cyclic AMP in granulosa cells, resulting in premature activation of terminal differentiation and, hence, arrest of follicle growth. (C) 1998 by Elsevier Science Inc.

引用

页码：306 / 307

页数：2

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