Emerging therapeutic targets for the treatment of hepatic fibrosis

被引：70
|
作者：
Fagone, Paolo [1 ]
Mangano, Katia [1 ]
Pesce, Antonio [2 ]
Portale, Teresa Rosanna [2 ]
Puleo, Stefano [2 ]
Nicoletti, Ferdinando [1 ]
机构：
[1] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
[2] Univ Catania, Dept Med & Surg Sci & Adv Technol, GF Ingrassia, Catania, Italy
来源：
DRUG DISCOVERY TODAY | 2016年 / 21卷 / 02期
关键词：
ATTENUATES LIVER FIBROSIS; STELLATE CELLS; SYSTEMIC-SCLEROSIS; INTERFERON-GAMMA; STEM-CELLS; EXPRESSION; INHIBITION; ACTIVATION; DISEASE; TRANSPLANTATION;
D O I：
10.1016/j.drudis.2015.10.015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Fibrosis represents a response to chronic injury, aimed at maintaining organ integrity. Hepatic fibrosis is mainly related to chronic viral hepatitis B or C (HBV or HCV), alcoholic and nonalcoholic steatohepatitis (NASH), and biliary diseases. A deep understanding of the cellular and molecular mechanisms underlying liver fibrosis has enabled the development of 'pathogenetic tailored' therapeutic interventions. However, effective drugs to prevent or revert hepatic fibrosis are still lacking. In this review, we discuss the cellular populations and the molecular pathways involved in liver fibrogenesis as well as the novel approaches currently being tested in clinical trials.
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页码：369 / 375
页数：7
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