New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum

被引：12

作者：

Zhao Yu-Dan ^{[1
]}

Zhang Xin ^{[1
]}

Yang Wan-Yue ^{[1
]}

Zhang Rui-Qi ^{[1
]}

Mu Lin-Tong ^{[1
]}

Han Ling ^{[3
]}

Lv Chong-Ning ^{[1
,2
]}

Lu Jin-Cai ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Liaoning Prov Key Lab TCM Resources Conservat & D, Shenyang 110016, Peoples R China

[3] NERC Pharmaceut Tradit Chinese Med, Benxi 117004, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2022年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Epimedium koreanum; Prenylflavonoid glycoside; Anti-pulmonary fibrosis; PRENYLATED FLAVONOL GLYCOSIDES; CONSTITUENTS; ICARIIN;

D O I：

10.1016/S1875-5364(21)60116-4

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities.

引用

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页码：221 / 228

页数：8

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