DBU/AgOTf Relay-Catalysis Enabled One-Pot Synthesis of 1,3-Dihydroisobenzofurans and Its Conversion to Indanones

被引：4

作者：

Wang, Jiazhuang ^{[1
]}

Huang, Hongtai ^{[1
]}

Gao, Haotian ^{[1
]}

Qin, Guiping ^{[1
]}

Xiao, Tiebo ^{[1
]}

Jiang, Yubo ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Sci, Kunming 650500, Yunnan, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 11期

基金：

中国国家自然科学基金;

关键词：

1,3-Dihydroisobenzofurans; Indanones; One-pot synthesis; 2-Alkynylbenzaldehyde; alpha-Diazo esters; O-ALKYNYL ACETOPHENONE; ALDOL-TYPE REACTION; C-H; CARBONYLATIVE CYCLIZATION; EFFICIENT SYNTHESIS; ARYL IODIDES; CASCADE; DERIVATIVES; REARRANGEMENT; INDENONES;

D O I：

10.1002/adsc.202200287

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A DBU/AgOTf relay-catalyzed one-pot reaction of 2-alkynylbenzaldehydes and alpha-diazo esters for the efficient construction of 1,3-dihydroisobenzofuran derivatives has been documented. This protocol can tolerate a wide range of substrates and its scalability is demonstrated by the gram-scale reaction. Moreover, the obtained 1,3-dihydroisobenzofurans can be converted to indanone derivatives by a AgOTf-catalyzed ring recombination process. Both of the resulting products, 1,3-dihydroisobenzofurans and indanones, are important structural units of a variety of pharmaceuticals and natural products, and their structures are clearly confirmed by single crystal X-ray diffraction analysis.

引用

页码：1896 / 1902

页数：7

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