Characterization of the down-regulated genes identified in preeclampsia placenta

被引：7
|
作者：
Kobayashi, Hiroshi [1 ]
机构：
[1] Nara Med Univ, Dept Obstet & Gynecol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan
来源：
HYPERTENSION IN PREGNANCY | 2016年 / 35卷 / 01期
关键词：
maternal; imprinting; Genetic conflict; paternal; preeclampsia; PATHOGENESIS; CONFLICT;
D O I：
10.3109/10641955.2015.1116555
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: We focus our attention on placental genes that are repressed in preeclampsia. Methods: A search was conducted through the online PubMed database. Results: A majority of the down-regulated genes appear to be evolved as the defense and protective mechanism for the mother, namely maternal fitness genes. A half of the down-regulated genes are also located within and in close proximity to known imprinted genes. Conclusion: Preeclampsia may be associated with either: (1) down-regulated expression of genes located in close proximity to known imprinted genes, (2) an imbalance in the maternal-fetal genetic response, or (3) an interaction of the two.
引用
收藏
页码：15 / 21
页数：7
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