Immune cells fold and damage fungal hyphae

被引：39

作者：

Bain, Judith M. ^{[1
]}

Alonso, M. Fernanda ^{[1
,8
]}

Childers, Delma S. ^{[1
]}

Walls, Catriona A. ^{[1
]}

Mackenzie, Kevin ^{[2
]}

Pradhan, Arnab ^{[1
,3
]}

Lewis, Leanne E. ^{[1
]}

Louw, Johanna ^{[1
]}

Avelar, Gabriela M. ^{[1
,9
]}

Larcombe, Daniel E. ^{[1
,3
]}

Netea, Mihai G. ^{[4
,5
,6
]}

Gow, Neil A. R. ^{[1
,3
]}

Brown, Gordon D. ^{[1
,3
]}

Erwig, Lars P. ^{[1
,7
]}

Brown, Alistair J. P. ^{[1
,3
]}

机构：

[1] Inst Med Sci, Aberdeen Fungal Grp, Foresterhill, Aberdeen AB25 2ZD, Scotland

[2] Inst Med Sci, Microscopy & Histol Facil, Foresterhill, Aberdeen AB25 2ZD, Scotland

[3] Univ Exeter, Med Res Council Ctr Med Mycol, Exeter EX4 4QD, Devon, England

[4] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands

[5] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Infect Dis, NL-6500 HB Nijmegen, Netherlands

[6] Univ Bonn, Dept Immunol & Metab, Life & Med Sci Inst, D-53115 Bonn, Germany

[7] Europe Middle East & Africa Innovat Ctr, Johnson Johnson Innovat, London W1G 0BG, England

[8] Roche Int Ltd, Dept Med, Montevideo 11300, Uruguay

[9] Univ Dundee, Div Mol Microbiol, Sch Life Sci, Dundee DD1 5EH, Scotland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2021年 / 118卷 / 15期

基金：

英国医学研究理事会; 欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

macrophages; fungal hyphae; mechanical force; podosomes; cytoskeleton; ACTIVATED PROTEIN-KINASE; CANDIDA-ALBICANS; MYOSIN-II; MECHANICAL FORCES; RECEPTOR; PHAGOCYTOSIS; RECOGNITION; DECTIN-1; PHOSPHORYLATION; STRESS;

D O I：

10.1073/pnas.2020484118

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example, Candida albicans can escape phagocytosis by activating cellular morphogenesis to form lengthy hyphae that are challenging to engulf. Through live imaging of C. albicans-macrophage interactions, we discovered that macrophages can counteract this by folding fungal hyphae. The folding of fungal hyphae is promoted by Dectin-1, beta 2-integrin, VASP, actin-myosin polymerization, and cell motility. Folding facilitates the complete engulfment of long hyphae in some cases and it inhibits hyphal growth, presumably tipping the balance toward successful fungal clearance.

引用

页数：8

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