Identification of 5-aminosalicylic acid, ciprofloxacin and azithromycin by abrasive stripping voltammetry

被引：49
|
作者：
Komorsky-Lovric, S
Nigovic, B
机构：
[1] Rudjer Boskovic Inst, Ctr Marine & Environm Res, Zagreb 10002, Croatia
[2] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 36卷 / 01期
关键词：
abrasive stripping voltammetry; microcrystals; 5-aminosalicylic acid; ciprofloxacin; azithromycin;
D O I：
10.1016/j.jpba.2004.05.008
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Solid microparticles of 5-aminosalicylic acid, ciprofloxacin, and azithromycin were mechanically immobilized on the surface of the paraffin impregnated graphite electrode and investigated by square-wave and cyclic voltammetry in order to develop a method for their qualitative determination. 5-Aminosalicylic acid is oxidized at 0.540V in the quasireversible electrode reaction, which is followed by the chemical transformation of the product, while ciprofloxacin and azithromycin are oxidized at 1.2V and 0.94V, respectively, in totally irreversible electrode reactions. The detection of these drugs in commercial dosage formulations is reported. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：81 / 89
页数：9
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