Topical Application of Tranexamic Acid in Primary Total Hip Arthroplasty: A Randomized Double-Blind Controlled Trial

被引：125
|
作者：
Yue, Chen [1 ]
Kang, Pengde [1 ]
Yang, Peiqing [1 ]
Xie, Jinwei [1 ]
Pei, Fuxing [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Orthoped Surg, West China Med Sch, Chengdu 610041, Sichuan Provinc, Peoples R China
来源：
JOURNAL OF ARTHROPLASTY | 2014年 / 29卷 / 12期
关键词：
topical; tranexamic acid; transfusions; blood loss; DVT; THA; REDUCES BLOOD-LOSS; TOTAL KNEE; TRANSFUSION RATES; REPLACEMENT; MANAGEMENT; REDUCTION; NEED;
D O I：
10.1016/j.arth.2014.03.032
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
So far, studies of topical tranexamic acid (TXA) in total hip arthroplasty (THA) were still lacking and controversial. We conducted this randomized double-blind controlled trial which included 101 patients to assess the effect of a high-dose 3 g topical TXA in THA. The results showed that 3 g topical TXA could significantly reduce transfusions from 22.4% to 5.7% (P < 0.05) without increasing the risk of deep vein thrombosis (DVT), pulmonary embolism (PE) and other complications. In addition, topical TXA significantly reduced total blood loss, reduced drain blood loss, and the drops of HB and HCT in topical TXA group were lower than control group. We concluded that 3 g topical TXA was effective and safe in reducing bleeding and transfusions in THA. (c) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：2452 / 2456
页数：5
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