Palladium(II) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

被引：40
|
作者：
Oliveira, Carolina G. [1 ,2 ,3 ]
Romero-Canelon, Isolda [3 ,4 ]
Silva, Monize M. [5 ]
Coverdale, James P. C. [5 ]
Maia, Pedro Ivo S. [6 ]
Batista, Alzir A. [5 ]
Castelli, Silvia [7 ]
Desideri, Alessandro [7 ]
Sadler, Peter J. [3 ]
Deflon, Victor M. [1 ]
机构：
[1] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13560970 Sao Carlos, SP, Brazil
[2] Fed Univ Uberldndia, Inst Chem, BR-38400902 Uberlandia, MG, Brazil
[3] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[4] Univ Birmingham, Sch Pharm, Birmingham B15 2TT, W Midlands, England
[5] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil
[6] Univ Fed Triangulo Mineiro, Dept Chem, BR-38025140 Uberaba, Brazil
[7] Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, Italy
来源：
DALTON TRANSACTIONS | 2019年 / 48卷 / 44期
基金：
巴西圣保罗研究基金会; 英国惠康基金; 英国工程与自然科学研究理事会;
关键词：
DNA; ANTICANCER; CAMPTOTHECINS; CYTOTOXICITY; FLUORESCENCE; PLATINUM(II); MECHANISM; CLEAVAGE; CELLS;
D O I：
10.1039/c9dt02570g
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells.
引用
下载
收藏
页码：16509 / 16517
页数：9
相关论文
共 50 条
  • [41] Dual inhibitors of epidermal growth factor receptor and topoisomerase IIα derived from a quinoline scaffold
    Chauhan, Monika
    Joshi, Gaurav
    Kler, Harveen
    Kashyap, Archana
    Amrutkar, Suyog M.
    Sharma, Praveen
    Bhilare, Kiran D.
    Banerjee, Uttam Chand
    Singh, Sandeep
    Kumar, Raj
    RSC ADVANCES, 2016, 6 (81): : 77717 - 77734
  • [42] Synthesis and spectroscopic studies on mercury(II) complexes of thiosemicarbazones derived from fluorenone and p-tolualdehyde
    Akinchan, NT
    Drozdzewski, PM
    Akinchan, R
    POLISH JOURNAL OF CHEMISTRY, 2000, 74 (09) : 1221 - 1229
  • [43] Synthesis and characterization of manganese(II) complexes derived, from 2-substituted benzaldehyde semicarbazones and thiosemicarbazones
    Kumar, Brajesh
    Sangal, S. K.
    Kumar, Arun
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2009, 86 (05) : 514 - 517
  • [44] Palladium(II) complexes containing cytokinins derived from 6-benzylaminopurine
    Trávnícek, Z
    Sipl, M
    Popa, I
    JOURNAL OF COORDINATION CHEMISTRY, 2005, 58 (16) : 1513 - 1521
  • [45] SYNTHESIS AND CHARACTERIZATION OF PALLADIUM(II) COMPLEXES DERIVED FROM AROMATIC THIOSEMICARBAZIDE DERIVATIVES
    BEKHEIT, MM
    ELEWADY, YA
    TAHA, FI
    MOSTAFA, SI
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1991, (02): : 178 - 183
  • [46] PALLADIUM(II) COMPLEXES OF SCHIFF-BASES DERIVED FROM HETEROCYCLIC ALDEHYDES
    GUPTA, VK
    JAIN, NC
    SHARMA, DK
    CURRENT SCIENCE, 1980, 49 (12): : 459 - 461
  • [47] Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II
    Xiong, Kai
    Qian, Chen
    Yuan, Yixian
    Wei, Lin
    Liao, Xinxing
    He, Liting
    Rees, Thomas W.
    Chen, Yu
    Wan, Jian
    Ji, Liangnian
    Chao, Hui
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (38) : 16631 - 16637
  • [48] Zinc(II) and palladium(II) Schiff base complexes derived from biologically active amines
    Westcott, SA
    Bourque, TA
    Nelles, ME
    Blacquiere, JM
    Coombs, RR
    Neilsen, JS
    Ringer, MK
    Smith, JC
    Zhang, HW
    Wheaton, SL
    Vogels, CM
    Baerlocher, FJ
    Decken, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U850 - U850
  • [49] Structural and biological studies of mononuclear palladium(II) complexes containing N-substituted thiosemicarbazones
    Prabhakaran, R.
    Renukadevi, S. V.
    Karvembu, R.
    Huang, R.
    Mautz, J.
    Huttner, G.
    Subashkumar, R.
    Natarajan, K.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (02) : 268 - 273
  • [50] Synthesis and NMR characterization of a series of quinoline-2-carboxaldehyde thiosemicarbazones and their palladium(II) complexes
    Lisic, Edward
    Chen, Jierou
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
12345