A sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid (GHB) and ethanol

被引：52
|
作者：
Louagie, HK
Verstraete, AG
DeSoete, CJ
Baetens, DG
Calle, PA
机构：
[1] University Hospital, Ghent
[2] Department of Clinical Biology, University Hospital 1B2, De Pintelaan 185
来源：
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 1997年 / 35卷 / 06期
关键词：
D O I：
10.3109/15563659709001237
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Objective: A case of a sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid (GHB) (125 mu g/mL), ethanol (134 mg/dL), and cannabinoids is described. Methods: GHB was determined by gas chromatography-mass spectrometry after acetonitrile precipitation and derivation with N-methyl-N-trimethylsilyltrifluoroacetamide using valproic acid as the internal standard. Conclusion: The described case illustrates the consequences of GHB overdose, GHB overdose should be considered in every case of unexplained sudden coma, i.e., without any evidence of head injury, intake of coma-inducing drugs, or increasing intracranial pressure, GHB overdose will be missed by routine toxicological screening.
引用
收藏
页码：591 / 594
页数：4
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