AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease

被引：23
|
作者：
Li, Chunying [1 ]
Keaney, John F., Jr. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01655 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 02期
关键词：
VASCULAR ENDOTHELIAL-CELLS; SIGNALING PATHWAY; OXIDATIVE STRESS; ANGIOTENSIN-II; MUSCLE-CELLS; IN-VIVO; C-ZETA; HEART; DYSFUNCTION; YEAST;
D O I：
10.1016/j.coph.2009.11.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
AMP-activated protein kinase (AMPK) was initially viewed as energy sensor and activated by increased intracellular concentrations of AMP following nutrient deprivation. Physiological or pathological stimuli that deplete cellular energy activate AMPK that coordinates a cellular program that limits further ATP depletion and promotes compensatory changes that maintain cellular ATP levels. Recent studies revealed novel roles of AMPK independent of energy status, thereby increasing our understanding of multi-functional roles of AMPK in cells important in pathogenesis of cardiovascular diseases. This enzyme represents an attractive therapeutic target for vascular disease treatment in the future.
引用
收藏
页码：111 / 115
页数：5
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